Fischer, Karina, van Lent, Debora Melo, Wolfsgruber, Steffen, Weinhold, Leonie, Kleineidam, Luca, Bickel, Horst, Scherer, Martin, Eisele, Marion, van den Bussche, Hendrik, Wiese, Birgitt, Koenig, Hans-Helmut, Weyerer, Siegfried, Pentzek, Michael, Roehr, Susanne ORCID: 0000-0001-9385-0669, Maier, Wolfgang, Jessen, Frank, Schmid, Matthias ORCID: 0000-0002-0788-0317, Riedel-Heller, Steffi G. and Wagner, Michael ORCID: 0000-0003-2589-6440 (2018). Prospective Associations between Single Foods, Alzheimer's Dementia and Memory Decline in the Elderly. Nutrients, 10 (7). BASEL: MDPI. ISSN 2072-6643

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Abstract

Background: Evidence whether single cognitive health foods could prevent cognitive decline is limited. We investigated whether dietary intake of red wine, white wine, coffee, green tea, olive oil, fresh fish, fruits and vegetables, red meat and sausages, assessed by a single-food-questionnaire, would be associated with either incident Alzheimer's dementia (AD) or verbal memory decline. Methods: Participants aged 75+ of the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) cohort were regularly followed over 10 years (n = 2622; n = 418 incident AD cases). Multivariable-adjusted joint modeling of repeated-measures and survival analysis was used, taking gender and Apolipoprotein E4 (APOE epsilon 4) genotype into account as possible effect modifiers. Results: Only higher red wine intake was associated with a lower incidence of AD (HR = 0.92; P = 0.045). Interestingly, this was true only for men (HR = 0.82; P < 0.001), while in women higher red wine intake was associated with a higher incidence of AD (HR = 1.15; P = 0.044), and higher white wine intake with a more pronounced memory decline over time (HR = -0.13; P = 0.052). Conclusion: We found no evidence for these single foods to be protective against cognitive decline, with the exception of red wine, which reduced the risk for AD only in men. Women could be more susceptible to detrimental effects of alcohol.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Fischer, KarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Lent, Debora MeloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weinhold, LeonieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kleineidam, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bickel, HorstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scherer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eisele, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Bussche, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiese, BirgittUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, Hans-HelmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weyerer, SiegfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pentzek, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roehr, SusanneUNSPECIFIEDorcid.org/0000-0001-9385-0669UNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmid, MatthiasUNSPECIFIEDorcid.org/0000-0002-0788-0317UNSPECIFIED
Riedel-Heller, Steffi G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
URN: urn:nbn:de:hbz:38-180768
DOI: 10.3390/nu10070852
Journal or Publication Title: Nutrients
Volume: 10
Number: 7
Date: 2018
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2072-6643
Language: English
Faculty: Faculty of Management, Economy and Social Sciences
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LONG-CHAIN OMEGA-3-FATTY-ACIDS; POLYUNSATURATED FATTY-ACIDS; DOSE-RESPONSE METAANALYSIS; TO-EVENT DATA; AGED 75 YEARS; COGNITIVE DECLINE; APOLIPOPROTEIN-E; ALCOHOL-CONSUMPTION; COFFEE CONSUMPTION; DIETARY PATTERNSMultiple languages
Nutrition & DieteticsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18076

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