Karanis, Panagiotis (2018). The truth about in vitro culture of Cryptosporidium species. Parasitology, 145 (7). S. 855 - 865. NEW YORK: CAMBRIDGE UNIV PRESS. ISSN 1469-8161

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Abstract

Cryptosporidium research has focused on the development of infection control, and effective therapy that has thus far been hampered by the inability to culture Cryptosporidium in vitro. Other limitations include inadequate animal models, cumbersome screening procedures for chemotherapeutic approaches and a lack of tools for genetic manipulation. These limitations can, however, be eased by the improvement and focused development of in vitro cultivation. The ability to culture relevant Cryptosporidium isolates in vitro and to propagate the life cycle stages that are responsible for causing disease in an infected host is still a critical link. This ability will facilitate other relevant approaches, e.g., the ability to knockout genes and the application of broader screening for drug discoveries and vaccine developments, in combination with new discoveries on the parasite's basic biology, genetic manipulation and new life cycle stages. Success in this effort represents an essential step towards significant progress in the control of cryptosporidiosis.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Karanis, PanagiotisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-184190
DOI: 10.1017/S0031182017001937
Journal or Publication Title: Parasitology
Volume: 145
Number: 7
Page Range: S. 855 - 865
Date: 2018
Publisher: CAMBRIDGE UNIV PRESS
Place of Publication: NEW YORK
ISSN: 1469-8161
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LIFE-CYCLE STAGES; WATERBORNE TRANSMISSION; PROTOZOAN PARASITES; HOST-CELL; DEVELOPING-COUNTRIES; WORLDWIDE OUTBREAKS; INFECTIOUS-DISEASES; PARVUM SPOROZOITES; GLOBAL BURDEN; MODELMultiple languages
ParasitologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18419

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