Universität zu Köln

Maurer, Christian, Ferreira, Arlindo R., Martel, Samuel, Lambertini, Matteo ORCID: 0000-0003-1797-5296, Ponde, Noam, Aftimos, Philippe, de Azambuja, Evandro ORCID: 0000-0001-9501-4509 and Piccart, Martine (2018). Endocrine therapy and palbociclib within a compassionate use program in heavily pretreated hormone receptor-positive, HER2-negative metastatic breast cancer. Breast, 39. S. 14 - 19. EDINBURGH: CHURCHILL LIVINGSTONE. ISSN 1532-3080

Full text not available from this repository.

Abstract

This is a single center retrospective analysis of patients with hormone receptor-positive, HER2-negative metastatic breast cancer progressing after >= 4 treatment lines treated with palbociclib in combination with endocrine therapy within a compassionate use program. Thirty-four patients were included between 10/2015 and 02/2017, the majority (82.4%) being previously treated with mTOR inhibitors. Disease control rate was 52.9% and 24.4% at week 12 and 24. Overall progression-free survival was 3.1 months with no difference between mTOR inhibitor-pretreated (3.5 months) and -naive patients (2.7 months; hazard ratio, 0.83). Toxicity profile in this population was comparable to that seen in previous trials. (C) 2018 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Maurer, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferreira, Arlindo R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Martel, Samuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Lambertini, Matteo UNSPECIFIED orcid.org/0000-0003-1797-5296 UNSPECIFIED Ponde, Noam UNSPECIFIED UNSPECIFIED UNSPECIFIED Aftimos, Philippe UNSPECIFIED UNSPECIFIED UNSPECIFIED de Azambuja, Evandro UNSPECIFIED orcid.org/0000-0001-9501-4509 UNSPECIFIED Piccart, Martine UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-185382
DOI:	10.1016/j.breast.2018.02.027
Journal or Publication Title:	Breast
Volume:	39
Page Range:	S. 14 - 19
Date:	2018
Publisher:	CHURCHILL LIVINGSTONE
Place of Publication:	EDINBURGH
ISSN:	1532-3080
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SOLID TUMORS; GUIDELINE; INHIBITOR; LETROZOLE; CRITERIA; RECIST Multiple languages Oncology; Obstetrics & Gynecology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18538