Universität zu Köln

Van der Veeken, Lennart, Russo, Francesca Maria, De Catte, Luc, Gratacos, Eduard ORCID: 0000-0002-7405-7224, Benachi, Alexandra, Ville, Yves, Nicolaides, Kypros, Berg, Christoph, Gardener, Glenn ORCID: 0000-0002-8123-0718, Persico, Nicola, Bagolan, Pietro ORCID: 0000-0003-3391-1209, Ryan, Greg ORCID: 0000-0002-5456-7622, Belfort, Michael A. and Deprest, Jan ORCID: 0000-0002-4920-945X (2018). Fetoscopic endoluminal tracheal occlusion and reestablishment of fetal airways for congenital diaphragmatic hernia. Gynecol. Surg., 15. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1613-2084

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Abstract

Background: Congenital diaphragmatic hernia (CDH) is a congenital anomaly with high mortality and morbidity mainly due to pulmonary hypoplasia and hypertension. Temporary fetal tracheal occlusion to promote prenatal lung growth may improve survival. Entrapment of lung fluid stretches the airways, leading to lung growth. Methods: Fetal endoluminal tracheal occlusion (FETO) is performed by percutaneous sono-endoscopic insertion of a balloon developed for interventional radiology. Reversal of the occlusion to induce lung maturation can be performed by fetoscopy, transabdominal puncture, tracheoscopy, or by postnatal removal if all else fails. Results: FETO and balloon removal have been shown safe in experienced hands. This paper deals with the technical aspects of balloon insertion and removal. While FETO is invasive, it has minimal maternal risks yet can cause preterm birth potentially offsetting its beneficial effects. Conclusion: For left-sided severe and moderate CDH, the procedure is considered investigational and is currently being evaluated in a global randomized clinical trial (https://www.totaltrial.eu/). The procedure can be clinically offered to fetuses with severe right-sided CDH.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Van der Veeken, Lennart UNSPECIFIED UNSPECIFIED UNSPECIFIED Russo, Francesca Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED De Catte, Luc UNSPECIFIED UNSPECIFIED UNSPECIFIED Gratacos, Eduard UNSPECIFIED orcid.org/0000-0002-7405-7224 UNSPECIFIED Benachi, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Ville, Yves UNSPECIFIED UNSPECIFIED UNSPECIFIED Nicolaides, Kypros UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Gardener, Glenn UNSPECIFIED orcid.org/0000-0002-8123-0718 UNSPECIFIED Persico, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED Bagolan, Pietro UNSPECIFIED orcid.org/0000-0003-3391-1209 UNSPECIFIED Ryan, Greg UNSPECIFIED orcid.org/0000-0002-5456-7622 UNSPECIFIED Belfort, Michael A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Deprest, Jan UNSPECIFIED orcid.org/0000-0002-4920-945X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-186607
DOI:	10.1186/s10397-018-1041-9
Journal or Publication Title:	Gynecol. Surg.
Volume:	15
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1613-2084
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IN-UTERO; LUNG AREA; FETUSES; MANAGEMENT; PREDICTORS; SURVIVAL; SURGERY; TRIAL; PLUG; ERA Multiple languages Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18660