Universität zu Köln

Sahebi, Firoozeh, Iacobelli, Simona, Sbianchi, Giulia, Koster, Linda, Blaise, Didier, Remenyi, Peter, Russell, Nigel H., Ljungman, Per, Kobbe, Guido, Apperley, Jane, Trneny, Marek, Krejci, Marta, Wiktor-Jedrzejczak, Wieslaw, Sanchez, James F., Schaap, Nicolaas ORCID: 0000-0001-7696-4752, Isaksson, Cecilia, Lenhoff, Stig, Browne, Paul ORCID: 0000-0001-5310-1487, Scheid, Christof, Wilson, Keith M. O., Yakoub-Agha, Ibrahim ORCID: 0000-0003-4524-8782, Muniz, Soledad Gonzalez, Schoenland, Stefan, Morris, Curly, Garderet, Laurent and Kroeger, Nicolaus (2018). Incidence of Second Primary Malignancies after Autologous Transplantation for Multiple Myeloma in the Era of Novel Agents. Biol. Blood Marrow Transplant., 24 (5). S. 930 - 937. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1523-6536

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Abstract

The advent of novel agents for multiple myeloma (MM) is cause for a re-examination of the incidence of second primary malignancies (SPM5). We examined the SPM rate in MM patients who were enrolled in the prospective observational CALM (Collaboration to Collect Autologous Transplant outcome in Lymphoma and Myeloma) study. Between 2008 and 2012, 3204 patients with MM underwent a first autologous hematopoietic stem cell transplantation. Plerixafor was used as a mobilizing agent for patients with poor (or potentially poor) stem cell mobilization as defined by the respective centers. A total of 135 patients developed SPM5, with a cumulative incidence of 5.3% (95% confidence interval, 4.4 to 6.3) at 72 months. Ninety-four patients developed solid tumors, 30 developed hematologic malignancies, and 11 developed an SPM of an unknown type. The cumulative incidence of known hematologic and solid malignancies were 1.4% and 3.6%, respectively, at 72 months. In a univariate analysis, use of radiotherapy, type of induction regimen, hematopoietic stem cell dose, poor mobilizer status, plerixafor use, and sex did not influence the cumulative incidence of SPMs. Only age over 65 years was statistically associated with an increased incidence. Overall, the incidence of SPMs was comparable to earlier estimations of SPMs in MM. (C) 2018 American Society for Blood and Marrow Transplantation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sahebi, Firoozeh UNSPECIFIED UNSPECIFIED UNSPECIFIED Iacobelli, Simona UNSPECIFIED UNSPECIFIED UNSPECIFIED Sbianchi, Giulia UNSPECIFIED UNSPECIFIED UNSPECIFIED Koster, Linda UNSPECIFIED UNSPECIFIED UNSPECIFIED Blaise, Didier UNSPECIFIED UNSPECIFIED UNSPECIFIED Remenyi, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Russell, Nigel H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ljungman, Per UNSPECIFIED UNSPECIFIED UNSPECIFIED Kobbe, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Apperley, Jane UNSPECIFIED UNSPECIFIED UNSPECIFIED Trneny, Marek UNSPECIFIED UNSPECIFIED UNSPECIFIED Krejci, Marta UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiktor-Jedrzejczak, Wieslaw UNSPECIFIED UNSPECIFIED UNSPECIFIED Sanchez, James F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaap, Nicolaas UNSPECIFIED orcid.org/0000-0001-7696-4752 UNSPECIFIED Isaksson, Cecilia UNSPECIFIED UNSPECIFIED UNSPECIFIED Lenhoff, Stig UNSPECIFIED UNSPECIFIED UNSPECIFIED Browne, Paul UNSPECIFIED orcid.org/0000-0001-5310-1487 UNSPECIFIED Scheid, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilson, Keith M. O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yakoub-Agha, Ibrahim UNSPECIFIED orcid.org/0000-0003-4524-8782 UNSPECIFIED Muniz, Soledad Gonzalez UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenland, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Morris, Curly UNSPECIFIED UNSPECIFIED UNSPECIFIED Garderet, Laurent UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroeger, Nicolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-187588
DOI:	10.1016/j.bbmt.2018.01.006
Journal or Publication Title:	Biol. Blood Marrow Transplant.
Volume:	24
Number:	5
Page Range:	S. 930 - 937
Date:	2018
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1523-6536
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; LENALIDOMIDE MAINTENANCE; MYELODYSPLASTIC SYNDROME; THERAPY; LEUKEMIA; METAANALYSIS; SECONDARY; NEOPLASMS; ADULTS; RISK Multiple languages Hematology; Immunology; Transplantation Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18758