Schroeter, Michael, Thayssen, Gunther and Kaiser, Julia (2018). Myasthenia gravis - Exacerbation and Crisis. Aktuelle Neurol., 45 (4). S. 271 - 278. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-9428

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Abstract

Myasthenic exacerbation and myasthenic crisis are highly critical incidences in myasthenia gravis. To this day, myasthenic crisis is associated with a lethality of 2 - 3%. In this paper, we review ways on how to avoid myasthenic exacerbation and crisis, elaborate on red flags and suggest ways to establish highly active therapy in time. This includes the reasonable use of cholinesterase inhibitors, immunoadsorption or plasma exchange, as well as immunoglobulins and steroids. Immunosuppressive agents and monoclonal antibody therapy add to the therapeutic options. Intensive care of mysthenic patients includes the management of dysphagia, and delirium. Importantly, the peri-operative management of patients undergoing thymectomy and weaning are specific challenges in the treatment of myasthenic patients in the ICU. Establishing timely and systematic immunosuppression and treating myasthenic patients in specialized outpatient centres help to avoid repetitive exacerbations and crises.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schroeter, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thayssen, GuntherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-188231
DOI: 10.1055/s-0043-118475
Journal or Publication Title: Aktuelle Neurol.
Volume: 45
Number: 4
Page Range: S. 271 - 278
Date: 2018
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1438-9428
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PERIOPERATIVE MANAGEMENT; CLINICAL-FEATURES; IMMUNOGLOBULIN; MORTALITYMultiple languages
Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18823

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