Universität zu Köln

Azimzade, Youness ORCID: 0000-0001-7363-7916, Saberi, Abbas Ali and Sahimi, Muhammad (2018). Role of the Interplay Between the Internal and External Conditions in Invasive Behavior of Tumors. Sci Rep, 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Tumor growth, which plays a central role in cancer evolution, depends on both the internal features of the cells, such as their ability for unlimited duplication, and the external conditions, e.g., supply of nutrients, as well as the dynamic interactions between the two. A stem cell theory of cancer has recently been developed that suggests the existence of a subpopulation of self-renewing tumor cells to be responsible for tumorigenesis, and is able to initiate metastatic spreading. The question of abundance of the cancer stem cells (CSCs) and its relation to tumor malignancy has, however, remained an unsolved problem and has been a subject of recent debates. In this paper we propose a novel model beyond the standard stochastic models of tumor development, in order to explore the effect of the density of the CSCs and oxygen on the tumor's invasive behavior. The model identifies natural selection as the underlying process for complex morphology of tumors, which has been observed experimentally, and indicates that their invasive behavior depends on both the number of the CSCs and the oxygen density in the microenvironment. The interplay between the external and internal conditions may pave the way for a new cancer therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Azimzade, Youness UNSPECIFIED orcid.org/0000-0001-7363-7916 UNSPECIFIED Saberi, Abbas Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED Sahimi, Muhammad UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-189369
DOI:	10.1038/s41598-018-24418-8
Journal or Publication Title:	Sci Rep
Volume:	8
Date:	2018
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANCER STEM-CELLS; FRACTAL DIMENSION; MELANOMA; GROWTH; DYNAMICS; MODEL; FLUCTUATIONS; METABOLISM; LACUNARITY; MORPHOLOGY Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18936