Universität zu Köln

Moraru, Alexandra, Wiederstein, Janica, Pfaff, Daniel, Fleming, Thomas, Miller, Aubry K., Nawroth, Peter and Teleman, Aurelio A. (2018). Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes. Cell Metab., 27 (4). S. 926 - 943. CAMBRIDGE: CELL PRESS. ISSN 1932-7420

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Abstract

The molecular causes of type 2 diabetes (T2D) are not well understood. Both type 1 diabetes (T1D) and T2D are characterized by impaired insulin signaling and hyperglycemia. From analogy to T1D, insulin resistance and hyperglycemia are thought to also play causal roles in T2D. Recent clinical studies, however, found that T2D patients treated to maintain glycemia below the diabetes definition threshold (HbA(1c) < 6.5%) still develop diabetic complications. This suggests additional insulin-and glucose-independent mechanisms could be involved in T2D progression and/or initiation. T2D patients have elevated levels of the metabolite methylglyoxal (MG). We show here, using Drosophila glyoxalase 1 knockouts, that animals with elevated methylglyoxal recapitulate several core aspects of T2D: insulin resistance, obesity, and hyperglycemia. Thus elevated MG could constitute one root cause of T2D, suggesting that the molecular causes of elevated MG warrant further study.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moraru, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiederstein, Janica UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfaff, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Fleming, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Miller, Aubry K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nawroth, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Teleman, Aurelio A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-189720
DOI:	10.1016/j.cmet.2018.02.003
Journal or Publication Title:	Cell Metab.
Volume:	27
Number:	4
Page Range:	S. 926 - 943
Date:	2018
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1932-7420
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DICARBONYL DETOXIFICATION; CARDIOVASCULAR-DISEASE; INTENSIVE TREATMENT; ALDOSE REDUCTASE; GLYCEMIC CONTROL; PROTEIN; STRESS; HYPERGLYCEMIA; PERSPECTIVE; DROSOPHILA Multiple languages Cell Biology; Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18972