Universität zu Köln

Sertznig, Helene ORCID: 0000-0001-8204-7926, Hillebrand, Frank, Erkelenz, Steffen, Schaal, Heiner and Widera, Marek ORCID: 0000-0001-5417-9307 (2018). Behind the scenes of HIV-1 replication: Alternative splicing as the dependency factor on the quiet. Virology, 516. S. 176 - 189. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 0042-6822

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Abstract

Alternative splicing plays a key role in the HIV-1 life cycle and is essential to maintain an equilibrium of mRNAs that encode viral proteins and polyprotein-isoforms. In particular, since all early HIV-1 proteins are expressed from spliced intronless and late enzymatic and structural proteins from intron containing, i.e. splicing repressed viral mRNAs, cellular splicing factors and splicing regulatory proteins are crucial for the replication capacity. In this review, we will describe the complex network of cis-acting splicing regulatory elements (SREs), which are mainly localized in the neighbourhoods of all HIV-1 splice sites and warrant the proper ratio of individual transcript isoforms. Since SREs represent binding sites for trans-acting cellular splicing factors interacting with the cellular spliceosomal apparatus we will review the current knowledge of interactions between viral RNA and cellular proteins as well as their impact on viral replication. Finally, we will discuss potential therapeutic approaches targeting HIV-1 alternative splicing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sertznig, Helene UNSPECIFIED orcid.org/0000-0001-8204-7926 UNSPECIFIED Hillebrand, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Erkelenz, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaal, Heiner UNSPECIFIED UNSPECIFIED UNSPECIFIED Widera, Marek UNSPECIFIED orcid.org/0000-0001-5417-9307 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-194341
DOI:	10.1016/j.virol.2018.01.011
Journal or Publication Title:	Virology
Volume:	516
Page Range:	S. 176 - 189
Date:	2018
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	0042-6822
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-IMMUNODEFICIENCY-VIRUS; PRE-MESSENGER-RNA; SUICIDE GENE-THERAPY; TYPE-1 TAT EXON-2; TRANSLATION INITIATION; SITE SELECTION; ANTIRETROVIRAL THERAPY; REGULATORY ELEMENTS; SILENCER ELEMENT; DRUG-RESISTANCE Multiple languages Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19434