Universität zu Köln

Barbui, Tiziano, Thiele, Jurgen, Gisslinger, Heinz, Kvasnicka, Hans Michael, Vannucchi, Alessandro M., Guglielmelli, Paola ORCID: 0000-0003-1809-284X, Orazi, Attilio and Tefferi, Ayalew (2018). The 2016 WHO classification and diagnostic criteria for myeloproliferative neoplasms: document summary and in-depth discussion. Blood Cancer J., 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2044-5385

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Abstract

The new edition of the 2016 World Health Organization (WHO) classification system for tumors of the hematopoietic and lymphoid tissues was published in September 2017. Under the category of myeloproliferative neoplasms (MPNs), the revised document includes seven subcategories: chronic myeloid leukemia, chronic neutrophilic leukemia, polycythemia vera (PV), primary myelofibrosis (PMF), essential thrombocythemia (ET), chronic eosinophilic leukemianot otherwise specified and MPN, unclassifiable (MPN-U); of note, mastocytosis is no longer classified under the MPN category. In the current review, we focus on the diagnostic criteria for JAK2/CALR/MPL mutation-related MPNs: PV, ET, and PMF. In this regard, the 2016 changes were aimed at facilitating the distinction between masked PV and JAK2-mutated ET and between prefibrotic/early and overtly fibrotic PMF. In the current communication, we (i) provide practically useful resource tables and graphs on the new diagnostic criteria including outcome, (ii) elaborate on the rationale for the 2016 changes, (iii) discuss the complementary role of mutation screening, (iv) address ongoing controversies and propose solutions, (v) attend to the challenges of applying WHO criteria in routine clinical practice, and (vi) outline future directions from the perspectives of the clinical pathologist.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Barbui, Tiziano UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Jurgen UNSPECIFIED UNSPECIFIED UNSPECIFIED Gisslinger, Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Kvasnicka, Hans Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Vannucchi, Alessandro M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Guglielmelli, Paola UNSPECIFIED orcid.org/0000-0003-1809-284X UNSPECIFIED Orazi, Attilio UNSPECIFIED UNSPECIFIED UNSPECIFIED Tefferi, Ayalew UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-196054
DOI:	10.1038/s41408-018-0054-y
Journal or Publication Title:	Blood Cancer J.
Volume:	8
Date:	2018
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2044-5385
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WORLD-HEALTH-ORGANIZATION; BONE-MARROW BIOPSY; CHRONIC IDIOPATHIC MYELOFIBROSIS; MASKED POLYCYTHEMIA-VERA; BCR-ABL TRANSLOCATION; TYROSINE KINASE JAK2; LONG-TERM SURVIVAL; ESSENTIAL THROMBOCYTHEMIA; CALRETICULIN MUTATIONS; HYPEREOSINOPHILIC SYNDROME Multiple languages Oncology; Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19605