Garg, Neeraj, Hansson, Annelie, Knych, Heather K., Stanley, Scott D., Thevis, Mario, Bondesson, Ulf, Hedeland, Mikael and Globisch, Daniel ORCID: 0000-0002-4526-5788 (2018). Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control. Org. Biomol. Chem., 16 (5). S. 698 - 703. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1477-0539

Full text not available from this repository.

Abstract

Selective androgen receptor modulators (SARMs) are a class of androgen receptor drugs, which have a high potential to be performance enhancers in human and animal sports. Arylpropionamides are one of the major SARM classes and get rapidly metabolized significantly complicating simple detection of misconduct in blood or urine sample analysis. Specific drug-derived metabolites are required as references due to a short half-life of the parent compound but are generally lacking. The difficulty in metabolism studies is the determination of the correct regio and stereoselectivity during metabolic conversion processes. In this study, we have elucidated and verified the chemical structure of two major equine arylpropionamide-based SARM metabolites using a combination of chemical synthesis and liquid chromatography- mass spectrometry (LC-MS) analysis. These synthesized SARM-derived metabolites can readily be utilized as reference standards for routine mass spectrometry-based doping control analysis of at least three commonly used performance-enhancing drugs to unambigously identify misconduct.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Garg, NeerajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansson, AnnelieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knych, Heather K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stanley, Scott D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thevis, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bondesson, UlfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hedeland, MikaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Globisch, DanielUNSPECIFIEDorcid.org/0000-0002-4526-5788UNSPECIFIED
URN: urn:nbn:de:hbz:38-196121
DOI: 10.1039/c7ob03030d
Journal or Publication Title: Org. Biomol. Chem.
Volume: 16
Number: 5
Page Range: S. 698 - 703
Date: 2018
Publisher: ROYAL SOC CHEMISTRY
Place of Publication: CAMBRIDGE
ISSN: 1477-0539
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
URINARY METABOLITES; ANDARINE S-4; S1; IDENTIFICATION; FLUTAMIDE; S22; S4Multiple languages
Chemistry, OrganicMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19612

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item