Pauls, K. A. M., Broeckelmann, P. J., Hammesfahr, S., Becker, J., Hellerbach, A., Visser-Vandewalle, V., Dembek, T. A., Meister, I. G. and Timmermann, L. (2018). Dysarthria in pallidal Deep Brain Stimulation in dystonia depends on the posterior location of active electrode contacts: a pilot study. Parkinsonism Relat. Disord., 47. S. 71 - 76. OXFORD: ELSEVIER SCI LTD. ISSN 1873-5126

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Abstract

Background: Pallidal Deep Brain Stimulation (GPi-DBS) is an efficient treatment for primary dystonia. We investigated stimulation-induced dysarthria, which is the most frequent side-effect of GPi-DBS. Methods: Speech was recorded while reading a standard text, and performing rapid syllable repetitions ON and OFF DBS in ten dystonia patients (6 men; 3 cervical, 4 segmental, 3 generalized, unselected for DBS-related speech impairments). Speech and articulation rate, pauses, and syllable repetition rates were extracted via acoustic analysis. Locations of active stimulation contacts and volumes of tissue activated (VTA) were calculated. Results: The number of pauses increased significantly ON vs. OFF stimulation (Wilcoxon test, p < 0.05). More posteriorly localized active contacts were associated with slower syllable repetition (Pearson correlation, p < 0.05). VTA size did not correlate with any measure of dysarthria. Conclusion: Using quantitative acoustic signal analysis, this study demonstrates that GPi-DBS alters motor aspects of speech. Both inadvertent stimulation of parts of the internal capsule, or interference with GPi function and outflow are possible causes. Understanding causes of GPi-DBS-induced speech changes can improve DBS programming. (C) 2017 The Authors. Published by Elsevier Ltd.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Pauls, K. A. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broeckelmann, P. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hammesfahr, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellerbach, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser-Vandewalle, V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dembek, T. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meister, I. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-197490
DOI: 10.1016/j.parkreldis.2017.11.002
Journal or Publication Title: Parkinsonism Relat. Disord.
Volume: 47
Page Range: S. 71 - 76
Date: 2018
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1873-5126
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SEGMENTAL DYSTONIA; ADVERSE EVENTS; DBS; MANAGEMENTMultiple languages
Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19749

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