Universität zu Köln

Siribbal, Shifaa M., Schlaefer, Johannes, Ilyas, Shaista, Hu, Zhangjun ORCID: 0000-0001-9905-0881, Uvdal, Kajsa, Valldor, Martin and Mathur, Sanjay (2018). Air-Stable Gadolinium Precursors for the Facile Microwave-Assisted Synthesis of Gd2O3 Nanocontrast Agents for Magnetic Resonance Imaging. Cryst. Growth Des., 18 (2). S. 633 - 642. WASHINGTON: AMER CHEMICAL SOC. ISSN 1528-7505

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Abstract

Using metal organic precursors in materials synthesis remains a challenge due to their high moisture susceptibility. In this work, we describe a facile methodology for the synthesis of Gd2O3-based contrast agents from two new gadolinium-based complexes. [Gd(PyTFP)(4)] (PyH) 1 (PyTFP = C8H5NOF3, Py = C5H5N) and [Gd(DMOTFP)(3)Py] 2 (DMOTFP = C8H7NO2F3) were synthesized via a classical ligand exchange reaction of [Gd{N(SiMe3)(2)}(3)] under inert conditions. As a result, X-ray diffraction analysis revealed a distorted square antiprismatic coordination and an augmented triangular prismatic arrangement of ligands around gadolinium atoms in 1 and 2, respectively. It also showed that 1 is an anionic complex of formula [Gd(PyTFP)(4)](PyH), while a neutral tris-compound, [Gd(DMOTFP)(3)Py], was obtained as a pyridine adduct in 2. Fast and reproducible microwave-assisted decomposition of 1 and 2 provided homogeneous Gd(OH)(3) nanorods at mild temperature without using any surfactant or capping reagent. As-synthesized nanorods were easily transformed into a cubic phase of Gd2O3 nanoparticles by thermal treatment under ambient conditions. The magnetic measurement showed the typical paramagnetic behavior of the Gd2O3 nanoparticles (NPs). The cytotoxicity profile demonstrates the biocompatibility and negligible toxicity of the as-synthesized nanoprobes. The suggested approach provides a new class of gadolinium-based precursors which allows facile synthesis of highly crystalline Gd2O3 NPs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Siribbal, Shifaa M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlaefer, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Ilyas, Shaista UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Zhangjun UNSPECIFIED orcid.org/0000-0001-9905-0881 UNSPECIFIED Uvdal, Kajsa UNSPECIFIED UNSPECIFIED UNSPECIFIED Valldor, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathur, Sanjay UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-197639
DOI:	10.1021/acs.cgd.7b00787
Journal or Publication Title:	Cryst. Growth Des.
Volume:	18
Number:	2
Page Range:	S. 633 - 642
Date:	2018
Publisher:	AMER CHEMICAL SOC
Place of Publication:	WASHINGTON
ISSN:	1528-7505
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHEMICAL-VAPOR-DEPOSITION; ATOMIC LAYER DEPOSITION; OXIDE THIN-FILMS; CONTRAST AGENTS; LONGITUDINAL RELAXIVITY; METAL-COMPLEXES; DRUG-DELIVERY; NANOPARTICLES; NANOCRYSTALS; DESIGN Multiple languages Chemistry, Multidisciplinary; Crystallography; Materials Science, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19763