Universität zu Köln

Miroshnikova, Yekaterina A., Le, Huy Q., Schneider, David, Thalheim, Torsten, Ruebsam, Matthias, Bremicker, Nadine, Polleux, Julien, Kamprad, Nadine, Tarantola, Marco, Wang, Irene, Balland, Martial, Niessen, Carien M., Galle, Joerg and Wickstroem, Sara A. (2018). Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification. Nat. Cell Biol., 20 (1). S. 69 - 84. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4679

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Abstract

To establish and maintain organ structure and function, tissues need to balance stem cell proliferation and differentiation rates and coordinate cell fate with position. By quantifying and modelling tissue stress and deformation in the mammalian epidermis, we find that this balance is coordinated through local mechanical forces generated by cell division and delamination. Proliferation within the basal stem/progenitor layer, which displays features of a jammed, solid-like state, leads to crowding, thereby locally distorting cell shape and stress distribution. The resulting decrease in cortical tension and increased cell-cell adhesion trigger differentiation and subsequent delamination, reinstating basal cell layer density. After delamination, cells establish a high-tension state as they increase myosin II activity and convert to E-cadherin-dominated adhesion, thereby reinforcing the boundary between basal and suprabasal layers. Our results uncover how biomechanical signalling integrates single-cell behaviours to couple proliferation, cell fate and positioning to generate a multilayered tissue.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Miroshnikova, Yekaterina A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Le, Huy Q. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Thalheim, Torsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruebsam, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Bremicker, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Polleux, Julien UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamprad, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Tarantola, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Irene UNSPECIFIED UNSPECIFIED UNSPECIFIED Balland, Martial UNSPECIFIED UNSPECIFIED UNSPECIFIED Niessen, Carien M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Galle, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Wickstroem, Sara A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-200813
DOI:	10.1038/s41556-017-0005-z
Journal or Publication Title:	Nat. Cell Biol.
Volume:	20
Number:	1
Page Range:	S. 69 - 84
Date:	2018
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-4679
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language E-CADHERIN; IN-VITRO; TERMINAL DIFFERENTIATION; TISSUE ARCHITECTURE; ORGANIZATION; DYNAMICS; POLARITY; SURFACE; GROWTH; SHAPE Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20081