Universität zu Köln

Weber, Michael, Schaer, Jonas, Walther, Grit, Kaerger, Kerstin, Steinmann, Joerg, Rath, Peter-Michael, Spiess, Birgit, Buchheidt, Dieter ORCID: 0000-0002-4425-6134, Hamprecht, Axel ORCID: 0000-0003-1449-5780 and Kurzai, Oliver (2018). FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus. Med. Mycol., 56 (1). S. 117 - 121. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2709

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Abstract

Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become an important diagnostic tool. We set up the database FunResDB (www.nrz-myk.de/funresdb) to gather all available information about CYP51A-dependent azole resistance from published literature. In summary, the screening resulted in 79 CYP51A variants, which are linked to 59 nonsynonymous mutations. A tailor-made online sequence analysis tool allows for genotypic susceptibility testing of A. fumigatus.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weber, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaer, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Walther, Grit UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaerger, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinmann, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Rath, Peter-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Spiess, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Buchheidt, Dieter UNSPECIFIED orcid.org/0000-0002-4425-6134 UNSPECIFIED Hamprecht, Axel UNSPECIFIED orcid.org/0000-0003-1449-5780 UNSPECIFIED Kurzai, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-205031
DOI:	10.1093/mmy/myx015
Journal or Publication Title:	Med. Mycol.
Volume:	56
Number:	1
Page Range:	S. 117 - 121
Date:	2018
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2709
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AZOLE RESISTANCE Multiple languages Infectious Diseases; Mycology; Veterinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20503