Universität zu Köln

Moesges, Ralph, Rohdenburg, Christina, Eichel, Andrea, Zadoyan, Gregor, Kasche, Elena-Manja, Shah-Hosseini, Kija ORCID: 0000-0001-9616-6942, Lehmacher, Walter, Schmalz, Petra and Compalati, Enrico (2017). Dose-finding study of carbamylated monomeric allergoid tablets in grass-allergic rhinoconjunctivitis patients. Immunotherapy, 9 (15). S. 1225 - 1239. LONDON: FUTURE MEDICINE LTD. ISSN 1750-7448

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Abstract

Aim: To determine the optimal effective and safe dose of sublingual immunotherapy tablets containing carbamylated monomeric allergoids in patients with grass pollen-induced allergic rhinoconjunctivitis. Methods: In this prospective, randomized, double-blind, active-controlled, multicenter, Phase II study, four different daily doses were applied preseasonally for 12 weeks. Results: Of 158 randomized adults, 155 subjects (safety population) received 300 units of allergy (UA)/day (n=36), 600 UA/day (n=43), 1000 UA/day (n=39), or 2000 UA/day (n=37). After treatment, 54.3, 47.6, 59.0 and 51.4% of patients, respectively, ceased to react to the highest allergen concentration in a conjunctival provocation test. Furthermore, the response threshold improved in 70.4, 62.9, 76.7 and 66.7% of patients, respectively. No serious adverse events occurred. Conclusion: This study found 1000 UA/day to be the optimal effective and safe dose.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moesges, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED Rohdenburg, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichel, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Zadoyan, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Kasche, Elena-Manja UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah-Hosseini, Kija UNSPECIFIED orcid.org/0000-0001-9616-6942 UNSPECIFIED Lehmacher, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmalz, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Compalati, Enrico UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-212556
DOI:	10.2217/imt-2017-0058
Journal or Publication Title:	Immunotherapy
Volume:	9
Number:	15
Page Range:	S. 1225 - 1239
Date:	2017
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1750-7448
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUBLINGUAL IMMUNOTHERAPY; DOUBLE-BLIND; CLINICAL-EFFICACY; PROVOCATION TEST; POLLEN; SAFETY; RHINITIS; EXTRACT; CONJUNCTIVAL; TRIALS Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21255