Universität zu Köln

von Jeinsen, Beatrice, Kraus, Daniel ORCID: 0000-0002-6351-3706, Palapies, Lars, Tzikas, Stergios ORCID: 0000-0002-7811-5620, Zeller, Tanja, Schauer, Anne, Drechsler, Christiane, Bickel, Christoph, Baldus, Stephan, Lackner, Karl J., Muenzel, Thomas, Blankenberg, Stefan, Zeiher, Andreas M. and Keller, Till (2017). Urinary neutrophil gelatinase-associated lipocalin and cystatin C compared to the estimated glomerular filtration rate to predict risk in patients with suspected acute myocardial infarction. Int. J. Cardiol., 245. S. 6 - 13. CLARE: ELSEVIER IRELAND LTD. ISSN 1874-1754

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Abstract

Introduction: Impaired renal function, reflected by estimated glomerular filtration rate (eGFR) or cystatin C, is a strong risk predictor in the presence of acute myocardial infarction (AMI). Urinary neutrophil gelatinase associated lipocalin (uNGAL) is an early marker of acute kidney injury. uNGAL might also be a good predictor of outcome in patients with cardiovascular disease. Aim of the present study was to evaluate the prognostic value of uNGAL compared to eGFR and cystatin C in patients with suspected AMI. Methods: 1818 patients were enrolled with suspected AMI. Follow-up information on the combined endpoint of death or non-fatal myocardial infarction was obtained 6 months after enrolment and was available in 1804 patients. 63 events (3.5%) were registered. Results: While cystatin C and eGFR were strong risk predictors for the primary endpoint even adjusted for several variables, uNGAL was not independently associated with outcome: When applied continuously uNGAL was associated with outcome but did not remain a statistically significant predictor after several adjustments (i.e. eGFR). By adding cystatin C or uNGAL to GRACE risk score variables, only cystatin C could improve the predictive value while uNGAL showed no improvement. Conclusion: We could show that cystatin C is an independent risk predictor in patients with suspected AMI and cystatin C can add improvement to the commonly used GRACE risk score. In contrast uNGAL is not independently associated with outcome and seems not to add further prognostic information to GRACE risk score. (C) 2017 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Jeinsen, Beatrice UNSPECIFIED UNSPECIFIED UNSPECIFIED Kraus, Daniel UNSPECIFIED orcid.org/0000-0002-6351-3706 UNSPECIFIED Palapies, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Tzikas, Stergios UNSPECIFIED orcid.org/0000-0002-7811-5620 UNSPECIFIED Zeller, Tanja UNSPECIFIED UNSPECIFIED UNSPECIFIED Schauer, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Drechsler, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Bickel, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Lackner, Karl J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Muenzel, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Blankenberg, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeiher, Andreas M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Keller, Till UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-214259
DOI:	10.1016/j.ijcard.2017.07.086
Journal or Publication Title:	Int. J. Cardiol.
Volume:	245
Page Range:	S. 6 - 13
Date:	2017
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1874-1754
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC HEART-FAILURE; ACUTE KIDNEY INJURY; CORONARY-ARTERY-DISEASE; ALL-CAUSE MORTALITY; CARDIOVASCULAR EVENTS; PROGNOSTIC VALUE; SERUM CREATININE; RENAL-FUNCTION; MARKER; EXPRESSION Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21425