Universität zu Köln

Fazeli, Walid, Zappettini, Stefania ORCID: 0000-0002-1238-9573, Marguet, Stephan Lawrence, Grendel, Jasper, Esclapez, Monique ORCID: 0000-0002-8558-1363, Bernard, Christophe and Isbrandt, Dirk (2017). Early-life exposure to caffeine affects the construction and activity of cortical networks in mice. Exp. Neurol., 295. S. 88 - 104. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2430

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Abstract

The consumption of psychoactive drugs during pregnancy can have deleterious effects on newborns. It remains unclear whether early-life exposure to caffeine, the most widely consumed psychoactive substance, alters brain development. We hypothesized that maternal caffeine ingestion during pregnancy and the early postnatal period in mice affects the construction and activity of cortical networks in offspring. To test this hypothesis, we focused on primary visual cortex (V1) as a model neocortical region. In a study design mimicking the daily consumption of approximately three cups of coffee during pregnancy in humans, caffeine was added to the drinking water of female mice and their offspring were compared to control offspring. Caffeine altered the construction of GABAergic neuronal networks in V1, as reflected by a reduced number of somatostatin-containing GABA neurons at postnatal days 6-7, with the remaining ones showing poorly developed dendritic arbors. These findings were accompanied by increased synaptic activity in vitro and elevated network activity in vivo in Vl. Similarly, in vivo hippocampal network activity was altered from the neonatal period until adulthood. Finally, caffeine-exposed offspring showed increased seizure susceptibility in a hyperthermia-induced seizure model. In summary, our results indicate detrimental effects of developmental caffeine exposure on mouse brain development. (C) 2017 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fazeli, Walid UNSPECIFIED UNSPECIFIED UNSPECIFIED Zappettini, Stefania UNSPECIFIED orcid.org/0000-0002-1238-9573 UNSPECIFIED Marguet, Stephan Lawrence UNSPECIFIED UNSPECIFIED UNSPECIFIED Grendel, Jasper UNSPECIFIED UNSPECIFIED UNSPECIFIED Esclapez, Monique UNSPECIFIED orcid.org/0000-0002-8558-1363 UNSPECIFIED Bernard, Christophe UNSPECIFIED UNSPECIFIED UNSPECIFIED Isbrandt, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-221231
DOI:	10.1016/j.expneurol.2017.05.013
Journal or Publication Title:	Exp. Neurol.
Volume:	295
Page Range:	S. 88 - 104
Date:	2017
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1090-2430
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXPERIMENTAL FEBRILE SEIZURES; ABNORMAL NEURONAL MIGRATION; DEVELOPING CEREBRAL-CORTEX; DEVELOPING VISUAL-CORTEX; TEMPORAL-LOBE EPILEPSY; GABAERGIC INTERNEURONS; CRITICAL-PERIOD; LONG-TERM; ELECTRICAL-ACTIVITY; PRENATAL EXPOSURE Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22123