Heppt, Markus V., Roesch, Alexander, Weide, Benjamin, Gutzmer, Ralf, Meier, Friedegund, Loquai, Carmen, Kaehler, Katharina C., Gesierich, Anja, Meissner, Markus, von Bubnoff, Dagmar, Goeppner, Daniela, Schlaak, Max, Pfoehler, Claudia, Utikal, Jochen ORCID: 0000-0001-5316-0241, Heinzerling, Lucie, Cosgarea, Ioana, Engel, Jutta, Eckel, Renate, Martens, Alexander, Mirlach, Laura, Satzger, Imke, Schubert-Fritschle, Gabriele, Tietze, Julia K. and Berking, Carola (2017). Prognostic factors and treatment outcomes in 444 patients with mucosal melanoma. Eur. J. Cancer, 81. S. 36 - 45. OXFORD: ELSEVIER SCI LTD. ISSN 1879-0852

Full text not available from this repository.

Abstract

Background: Mucosal melanoma (MM) is a rare but diverse cancer entity. Prognostic factors are not well established for Caucasians with MM. Patients and methods: We analysed the disease course of 444 patients from 15 German skin cancer centres. Disease progression was determined with the cumulative incidence function. Survival times were estimated with the Kaplan-Meier method. Prognostic parameters were identified with multivariate Cox regression analysis. Results: Common anatomic sites of primary tumours were head and neck (MMHN, 37.2%), female genital tract (MMFG, 30.4%) and anorectal region (MMAN, 21.8%). MMAN patients showed the highest vertical tumour thickness (p = 0.001), had a more advanced nodal status (p = 0.014) and a higher percentage of metastatic disease (p = 0.001) at diagnosis. Mutations of NRAS (13.8%), KIT (8.6%) and BRAF (6.4%) were evenly distributed across all tumour site groups. Local relapses were observed in 32.4% and most commonly occurred in the MMHN group (pZ0.016). Male gender (p = 0.047), advanced tumour stage (p = 0.001), nodal disease (p = 0.001) and incomplete resection status (p = 0.001) were independent risk factors for disease progression. Overall survival (OS) was highest in the MMFG group (p = 0.030) and in patients without ulceration (p = 0.004). Multivariate risk factors for OS were M stage at diagnosis (p = 0.002) and incomplete resection of the primary tumour (p = 0.001). Conclusion: In this large series of MM patients in a European population, anorectal MM was associated with the poorest prognosis. (C) 2017 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Heppt, Markus V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roesch, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weide, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gutzmer, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meier, FriedegundUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loquai, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaehler, Katharina C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gesierich, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meissner, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Bubnoff, DagmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goeppner, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlaak, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfoehler, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Utikal, JochenUNSPECIFIEDorcid.org/0000-0001-5316-0241UNSPECIFIED
Heinzerling, LucieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cosgarea, IoanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engel, JuttaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eckel, RenateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martens, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mirlach, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Satzger, ImkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schubert-Fritschle, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tietze, Julia K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berking, CarolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-223970
DOI: 10.1016/j.ejca.2017.05.014
Journal or Publication Title: Eur. J. Cancer
Volume: 81
Page Range: S. 36 - 45
Date: 2017
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1879-0852
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RETROSPECTIVE ANALYSIS; MALIGNANT-MELANOMA; KIT EXPRESSION; CANCER CENTER; SINONASAL; HEAD; NECK; MUTATIONS; EFFICACY; IMATINIBMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22397

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item