Paul, Christoph ORCID: 0000-0002-6458-0302, Heun, Christine, Mueller, Hans H., Fauser, Sascha, Kaymak, Hakan, Kazerounian, Sara, Sekundo, Walter, Mennel, Stefan, Meyer, Carsten H. ORCID: 0000-0002-0530-5298, Schmitz-Valckenberg, Steffen, Koss, Michael J., Feltgen, Nicolas and Bertelmann, Thomas (2017). IMPACT OF VITREORETINAL INTERFACE ARCHITECTURE ON SUCCESSFUL VITREOMACULAR TRACTION RESOLUTION IN EYES SCHEDULED FOR INTRAVITREAL OCRIPLASMIN THERAPY. Retin.-J. Retin. Vitr. Dis., 37 (7). S. 1252 - 1261. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1539-2864

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Abstract

Purpose: To evaluate the impact of the vitreoretinal interface architecture, in specific the angle between the posterior vitreous cortex and the internal limiting membrane, on vitreomacular traction (VMT) resolution in eyes treated with intravitreally injected ocriplasmin (Jetrea). Methods: Retrospective, multicenter cohort study and exploratory data analysis. Spectral domain optical coherence tomography assessments were performed before scheduled ocriplasmin injections. General (age and sex) as well as ocular variables (lens status, presence of epiretinal membrane formations, horizontal diameter of VMT, central retinal thickness, and in particular various prespecified angles between the posterior vitreous cortex and internal limiting membrane) were analyzed to evaluate their impact on successful VMT resolution. Results: Fifty-nine eyes of 59 patients were included. Univariate analysis of age (odds ratio [OR]: 0.881; 95% CI: [0.812-0.955]; P = 0.0022) and lens status (OR: 11.03; 95% CI: [2.23-54.57]; P = 0.0033) had a significant impact on successful VMT resolution, whereas sex (OR: 0.668; 95% CI: [0.126-2.065]; P = 0.4906), epiretinal membrane formation (OR: 0.581; 95% CI: [0.168-2.006]; P = 0.3903), horizontal diameter of VMT (OR: 0.99930; 95% CI: [0.99825-1.00035]; P = 0.1886), and central retinal thickness (OR: 0.9985; 95% CI: [0.9934-1.00436]; P = 0.56) failed. The angle at 500 mm apart from the fovea centralis, irrespective if measured nasally (OR: 1.135; 95% CI: [1.013-1.272]; P = 0.0289) or temporally (OR: 1.099; 95% CI: [1.001-1.208]; P = 0.0485), showed a significant correlation with VMT resolution. Conclusion: The angle between the posterior vitreous cortex and the internal limiting membrane 500 mm apart from the fovea centralis correlates with VMT resolution and may be a clinically useful marker for selection of patients to be treated with ocriplasmin. This observation needs to be proven in a prospective confirmatory investigation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Paul, ChristophUNSPECIFIEDorcid.org/0000-0002-6458-0302UNSPECIFIED
Heun, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, Hans H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fauser, SaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaymak, HakanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kazerounian, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sekundo, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mennel, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, Carsten H.UNSPECIFIEDorcid.org/0000-0002-0530-5298UNSPECIFIED
Schmitz-Valckenberg, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koss, Michael J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feltgen, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertelmann, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-226161
DOI: 10.1097/IAE.0000000000001371
Journal or Publication Title: Retin.-J. Retin. Vitr. Dis.
Volume: 37
Number: 7
Page Range: S. 1252 - 1261
Date: 2017
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1539-2864
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OPTICAL COHERENCE TOMOGRAPHY; MACULAR HOLES; MIVI-TRUST; ADHESION; OUTCOMES; EXPERIENCE; EFFICACYMultiple languages
OphthalmologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22616

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