Universität zu Köln

Lohmann, Philipp ORCID: 0000-0002-5360-046X, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Ceccon, Garry, Rapp, Marion, Sabel, Michael, Filss, Christian P., Kamp, Marcel A., Stegmayr, Carina ORCID: 0000-0003-4191-8734, Neumaier, Bernd ORCID: 0000-0001-5425-3116, Shah, Nadim J., Langen, Karl-Josef ORCID: 0000-0003-1101-5075 and Galldiks, Norbert ORCID: 0000-0002-2485-1796 (2017). Radiation injury vs. recurrent brain metastasis: combining textural feature radiomics analysis and standard parameters may increase F-18-FET PET accuracy without dynamic scans. Eur. Radiol., 27 (7). S. 2916 - 2928. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

We investigated the potential of textural feature analysis of O-(2-[F-18]fluoroethyl)-L-tyrosine (F-18-FET) PET to differentiate radiation injury from brain metastasis recurrence. Forty-seven patients with contrast-enhancing brain lesions (n = 54) on MRI after radiotherapy of brain metastases underwent dynamic F-18-FET PET. Tumour-to-brain ratios (TBRs) of F-18-FET uptake and 62 textural parameters were determined on summed images 20-40 min post-injection. Tracer uptake kinetics, i.e., time-to-peak (TTP) and patterns of time-activity curves (TAC) were evaluated on dynamic PET data from 0-50 min post-injection. Diagnostic accuracy of investigated parameters and combinations thereof to discriminate between brain metastasis recurrence and radiation injury was compared. Diagnostic accuracy increased from 81 % for TBRmean alone to 85 % when combined with the textural parameter Coarseness or Short-zone emphasis. The accuracy of TBRmax alone was 83 % and increased to 85 % after combination with the textural parameters Coarseness, Short-zone emphasis, or Correlation. Analysis of TACs resulted in an accuracy of 70 % for kinetic pattern alone and increased to 83 % when combined with TBRmax. Textural feature analysis in combination with TBRs may have the potential to increase diagnostic accuracy for discrimination between brain metastasis recurrence and radiation injury, without the need for dynamic F-18-FET PET scans. aEuro cent Textural feature analysis provides quantitative information about tumour heterogeneity aEuro cent Textural features help improve discrimination between brain metastasis recurrence and radiation injury aEuro cent Textural features might be helpful to further understand tumour heterogeneity aEuro cent Analysis does not require a more time consuming dynamic PET acquisition.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Ceccon, Garry UNSPECIFIED UNSPECIFIED UNSPECIFIED Rapp, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Filss, Christian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamp, Marcel A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stegmayr, Carina UNSPECIFIED orcid.org/0000-0003-4191-8734 UNSPECIFIED Neumaier, Bernd UNSPECIFIED orcid.org/0000-0001-5425-3116 UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-226414
DOI:	10.1007/s00330-016-4638-2
Journal or Publication Title:	Eur. Radiol.
Volume:	27
Number:	7
Page Range:	S. 2916 - 2928
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1084
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOW-GRADE GLIOMA; STEREOTACTIC RADIOSURGERY; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; INTRATUMORAL HETEROGENEITY; FET PET; TUMORS; DIFFERENTIATION; DIAGNOSIS; RADIOTHERAPY; CANCER Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22641