Napp, Adriane E., Haase, Robert ORCID: 0000-0003-2311-8004, Laule, Michael, Schuetz, Georg M., Rief, Matthias, Dreger, Henryk, Feuchtner, Gudrun, Friedrich, Guy, Spacek, Miloslav, Suchanek, Vojtech, Kofoed, Klaus Fuglsang, Engstroem, Thomas, Schroeder, Stephen, Drosch, Tanja, Gutberlet, Matthias, Woinke, Michael, Maurovich-Horvat, Pal ORCID: 0000-0003-0885-736X, Merkely, Bela, Donnelly, Patrick, Ball, Peter, Dodd, Jonathan D., Quinn, Martin, Saba, Luca, Porcu, Maurizio, Francone, Marco, Mancone, Massimo, Erglis, Andrejs, Zvaigzne, Ligita, Jankauskas, Antanas, Sakalyte, Gintare, Haran, Tomasz, Ilnicka-Suckiel, Malgorzata, Bettencourt, Nuno ORCID: 0000-0002-9582-7881, Gama-Ribeiro, Vasco, Condrea, Sebastian, Benedek, Imre ORCID: 0000-0003-0051-4047, Adjic, Nada Cemerlic, Adjic, Oto, Rodriguez-Palomares, Jose, del Blanco, Bruno Garcia, Roditi, Giles, Berry, Colin, Davis, Gershan, Thwaite, Erica, Knuuti, Juhani ORCID: 0000-0003-3156-9593, Pietila, Mikko, Kepka, Cezary, Kruk, Mariusz, Vidakovic, Radosav, Neskovic, Aleksandar N., Diez, Ignacio, Lecumberri, Inigo, Geleijns, Jacob, Kubiak, Christine, Strenge-Hesse, Anke, Do, The-Hoang, Fromel, Felix, Gutierrez-Ibarluzea, Inaki ORCID: 0000-0002-4080-7963, Benguria-Arrate, Gaizka, Keiding, Hans, Katzer, Christoph, Mueller-Nordhorn, Jacqueline, Rieckmann, Nina ORCID: 0000-0002-6870-451X, Walther, Mario, Schlattmann, Peter and Dewey, Marc ORCID: 0000-0002-4402-2733 (2017). Computed tomography versus invasive coronary angiography: design and methods of the pragmatic randomised multicentre DISCHARGE trial. Eur. Radiol., 27 (7). S. 2957 - 2969. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

More than 3.5 million invasive coronary angiographies (ICA) are performed in Europe annually. Approximately 2 million of these invasive procedures might be reduced by noninvasive tests because no coronary intervention is performed. Computed tomography (CT) is the most accurate noninvasive test for detection and exclusion of coronary artery disease (CAD). To investigate the comparative effectiveness of CT and ICA, we designed the European pragmatic multicentre DISCHARGE trial funded by the 7th Framework Programme of the European Union (EC-GA 603266). In this trial, patients with a low-to-intermediate pretest probability (10-60 %) of suspected CAD and a clinical indication for ICA because of stable chest pain will be randomised in a 1-to-1 ratio to CT or ICA. CT and ICA findings guide subsequent management decisions by the local heart teams according to current evidence and European guidelines. Major adverse cardiovascular events (MACE) defined as cardiovascular death, myocardial infarction and stroke as a composite endpoint will be the primary outcome measure. Secondary and other outcomes include cost-effectiveness, radiation exposure, health-related quality of life (HRQoL), socioeconomic status, lifestyle, adverse events related to CT/ICA, and gender differences. The DISCHARGE trial will assess the comparative effectiveness of CT and ICA. aEuro cent Coronary artery disease (CAD) is a major cause of morbidity and mortality. aEuro cent Invasive coronary angiography (ICA) is the reference standard for detection of CAD. aEuro cent Noninvasive computed tomography angiography excludes CAD with high sensitivity. aEuro cent CT may effectively reduce the approximately 2 million negative ICAs in Europe. aEuro cent DISCHARGE addresses this hypothesis in patients with low-to-intermediate pretest probability for CAD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Napp, Adriane E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haase, RobertUNSPECIFIEDorcid.org/0000-0003-2311-8004UNSPECIFIED
Laule, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuetz, Georg M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rief, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dreger, HenrykUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feuchtner, GudrunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedrich, GuyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spacek, MiloslavUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suchanek, VojtechUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kofoed, Klaus FuglsangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engstroem, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroeder, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drosch, TanjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gutberlet, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woinke, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maurovich-Horvat, PalUNSPECIFIEDorcid.org/0000-0003-0885-736XUNSPECIFIED
Merkely, BelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Donnelly, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ball, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dodd, Jonathan D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quinn, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saba, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Porcu, MaurizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Francone, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mancone, MassimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erglis, AndrejsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zvaigzne, LigitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jankauskas, AntanasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sakalyte, GintareUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haran, TomaszUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ilnicka-Suckiel, MalgorzataUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bettencourt, NunoUNSPECIFIEDorcid.org/0000-0002-9582-7881UNSPECIFIED
Gama-Ribeiro, VascoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Condrea, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benedek, ImreUNSPECIFIEDorcid.org/0000-0003-0051-4047UNSPECIFIED
Adjic, Nada CemerlicUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adjic, OtoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez-Palomares, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
del Blanco, Bruno GarciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roditi, GilesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berry, ColinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davis, GershanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thwaite, EricaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knuuti, JuhaniUNSPECIFIEDorcid.org/0000-0003-3156-9593UNSPECIFIED
Pietila, MikkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kepka, CezaryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kruk, MariuszUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vidakovic, RadosavUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neskovic, Aleksandar N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diez, IgnacioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lecumberri, InigoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geleijns, JacobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kubiak, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strenge-Hesse, AnkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Do, The-HoangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fromel, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gutierrez-Ibarluzea, InakiUNSPECIFIEDorcid.org/0000-0002-4080-7963UNSPECIFIED
Benguria-Arrate, GaizkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keiding, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katzer, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller-Nordhorn, JacquelineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rieckmann, NinaUNSPECIFIEDorcid.org/0000-0002-6870-451XUNSPECIFIED
Walther, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlattmann, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dewey, MarcUNSPECIFIEDorcid.org/0000-0002-4402-2733UNSPECIFIED
URN: urn:nbn:de:hbz:38-226422
DOI: 10.1007/s00330-016-4620-z
Journal or Publication Title: Eur. Radiol.
Volume: 27
Number: 7
Page Range: S. 2957 - 2969
Date: 2017
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-1084
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CT ANGIOGRAPHY; CARDIAC-CATHETERIZATION; COST-EFFECTIVENESS; CLINICAL-TRIALS; CHEST-PAIN; TASK-FORCE; METAANALYSIS; PERFORMANCE; GUIDELINES; MANAGEMENTMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22642

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