Universität zu Köln

Bagshaw, Emma, Kuessner, Daniel, Posthumus, Jan, Escrig, Cesar, Blackney, Michael, Heimann, Sebastian Marcel and Cornely, Oliver Andreas (2017). The cost of treating mucormycosis with isavuconazole compared with standard therapy in the UK. Future Microbiol., 12 (6). S. 514 - 525. LONDON: FUTURE MEDICINE LTD. ISSN 1746-0921

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Abstract

Aim: Mucormycosis is a fungal infection associated with high mortality. Until recently, the only licensed treatments were amphotericin B (AMB) formulations. Isavuconazole (ISAV) is a new mucormycosis treatment. A UK-based economic model explored treatment costs with ISAV versus liposomal AMB followed by posaconazole. Materials & methods: As a matched case-control analysis showed similar efficacy for ISAV and AMB, a cost-minimization approach was taken. Direct costs - drug acquisition, monitoring and administration, and hospitalization costs - were estimated from the National Health Service perspective. Results: Per-patient costs for ISAV and liposomal AMB + posaconazole were UK(sic)26,810 and UK(sic)41,855, respectively, with savings primarily driven by drug acquisition and hospitalization costs. Conclusion: ISAV may reduce costs compared with standard mucormycosis therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bagshaw, Emma UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuessner, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Posthumus, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Escrig, Cesar UNSPECIFIED UNSPECIFIED UNSPECIFIED Blackney, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Heimann, Sebastian Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-231648
DOI:	10.2217/fmb-2016-0231
Journal or Publication Title:	Future Microbiol.
Volume:	12
Number:	6
Page Range:	S. 514 - 525
Date:	2017
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1746-0921
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIPOSOMAL AMPHOTERICIN-B; INVASIVE FUNGAL DISEASE; ECONOMIC BURDEN; UNITED-STATES; MORTALITY; INFECTIONS; GUIDELINES; DIAGNOSIS; FRANCE Multiple languages Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23164