Klapdor, Ruediger, Hillemanns, Peter, Woelber, Linn, Jueckstock, Julia, Hilpert, Felix, de Gregorio, Nikolaus, Iborra, Severine, Sehouli, Jalid, Habermann, Anika, Fuerst, Sophie Teresa, Strauss, Hans Georg, Baumann, Klaus, Thiel, Falk, Mustea, Alexander, Meier, Werner, Harter, Philipp, Wimberger, Pauline, Hanker, Lars, Schmalfeldt, Barbara, Canzler, Ulrich, Fehm, Tanja, Luyten, Alexander, Hellriegel, Martin, Kosse, Jens, Heiss, Christoph, Hantschmann, Peer, Mallmann, Peter, Tanner, Berno, Pfisterer, Jacobus, Richter, Barbara, Jager, Martin and Mahner, Sven (2017). Outcome After Sentinel Lymph Node Dissection in Vulvar Cancer: A Subgroup Analysis of the AGO-CaRE-1 Study. Ann. Surg. Oncol., 24 (5). S. 1314 - 1322. NEW YORK: SPRINGER. ISSN 1534-4681

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Abstract

Analyzing the large patient cohort of the multicenter AGO-CaRE-1 study, we compared isolated sentinel lymph node dissection (SLND) with radical lymph node dissection (LND) of the groin in relation to recurrence rates and survival. The AGO-CaRE-1 study retrospectively collected data on treatment patterns and follow-up of vulvar cancer patients [International Federation of Gynecology and Obstetrics (FIGO) stage 1B] treated at 29 gynecologic cancer centers between 1998 and 2008. This subgroup analysis evaluated the influence of SLND alone on progression-free survival (PFS) and overall survival (OS). In 487 (63.1%) of 772 included patients with tumors smaller than 4 cm, an LND was performed and no metastatic lymph nodes were detected (LN0). Another 69/772 (8.9%) women underwent SLND alone, showing a negative SLN (SLN0). Tumors in the LN0 group were larger and showed a deeper invasion (LN0 vs. SLN0 tumor diameter: 20.0 vs. 13.0 mm, p < 0.001; depth of invasion: 4.0 vs. 3.0 mm, p = 0.002). After a median follow-up of 33 months (0-156), no significant differences in relation to isolated groin recurrence rates (SLN0 3.0% vs. LN0 3.4%, p = 0.845) were detected. Similarly, univariate 3-year PFS analysis showed no significant differences between both groups (SLN0 82.7% vs. LN0 77.6%, p = 0.230). A multivariate Cox regression analysis, including tumor diameter, depth of invasion, age, grading, and lymphovascular space invasion was performed: PFS [hazard ratio (HR) 0.970, 95% confidence interval (CI) 0.517-1.821] and OS (HR 0.695, 95% CI 0.261-1.849) did not differ significantly between both cohorts. This subgroup analysis of the large AGO-CaRE-1 study showed similar results for groin LND and SLND alone with regard to recurrence rates and survival in node-negative patients with tumors < 4 cm.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Klapdor, RuedigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hillemanns, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woelber, LinnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jueckstock, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hilpert, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Gregorio, NikolausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iborra, SeverineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sehouli, JalidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Habermann, AnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuerst, Sophie TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strauss, Hans GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baumann, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiel, FalkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mustea, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meier, WernerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harter, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wimberger, PaulineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanker, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmalfeldt, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canzler, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fehm, TanjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luyten, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellriegel, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kosse, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heiss, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hantschmann, PeerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mallmann, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tanner, BernoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfisterer, JacobusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richter, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jager, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mahner, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-232942
DOI: 10.1245/s10434-016-5687-0
Journal or Publication Title: Ann. Surg. Oncol.
Volume: 24
Number: 5
Page Range: S. 1314 - 1322
Date: 2017
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1534-4681
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SQUAMOUS-CELL CARCINOMA; TERM-FOLLOW-UP; GROINSS-V; BIOPSY; COMPLICATIONS; MULTICENTER; METASTASIS; SURVIVAL; T1Multiple languages
Oncology; SurgeryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23294

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