Barragan, Eduardo, Breuer, Dieter and Doepfner, Manfred (2017). Efficacy and Safety of Omega-3/6 Fatty Acids, Methylphenidate, and a Combined Treatment in Children With ADHD. J. Atten. Disord., 21 (5). S. 433 - 442. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1557-1246

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Abstract

Objective: To compare efficacy of Omega-3/6 fatty acids (Equazen eye q (TM)) with methylphenidate (MPH) and combined MPH + Omega-3/6 in children with ADHD. Method: Participants (N = 90) were randomized to Omega-3/6, long-acting MPH, or combination for 12 months. ADHD symptoms were assessed using the ADHD Rating Scale and Clinical Global Impressions-Severity (CGI-S) scale. Results: ADHD symptoms decreased in all treatment arms. Although significant differences favoring Omega + MPH over Omega-3/6 alone were found for ADHD Total and Hyperactivity-Impulsivity subscales, results on the Inattention subscale were similar. CGI-S scores decreased slowly and consistently with Omega-3/6, compared with a rapid decrease and subsequent slight increase in the MPH-containing arms. Adverse events were numerically less frequent with Omega-3/6 or MPH + Omega-3/6 than MPH alone. Conclusion: The tested combination of Omega-3/6 fatty acids had similar effects to MPH, whereas the MPH + Omega combination appeared to have some tolerability benefits over MPH.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Barragan, EduardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breuer, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doepfner, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-232988
DOI: 10.1177/1087054713518239
Journal or Publication Title: J. Atten. Disord.
Volume: 21
Number: 5
Page Range: S. 433 - 442
Date: 2017
Publisher: SAGE PUBLICATIONS INC
Place of Publication: THOUSAND OAKS
ISSN: 1557-1246
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT; CONTROLLED-TRIAL; SUPPLEMENTATION; PREVALENCE; SYMPTOMS; DIETARY; RATES; MTAMultiple languages
Psychology, Developmental; PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23298

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