Sabashnikov, Anton, Heinen, Stephanie, Deppe, Antje Christin, Zeriouh, Mohamed, Weymann, Alexander, Slottosch, Ingo, Eghbalzadeh, Kaveh, Popov, Aron-Frederik ORCID: 0000-0003-4226-3004, Liakopoulos, Oliver, Rahmanian, Parwis B. ORCID: 0000-0002-3978-9251, Madershahian, Navid, Kroener, Axel, Choi, Yeong-Hoon, Kuhn-Regnier, Ferdinand, Simon, Andre R., Wahlers, Thorsten and Wippermann, Jens (2017). Impact of gender on long-term outcomes after surgical repair for acute Stanford A aortic dissection: a propensity score matched analysis. Interact Cardiovasc. Thorac. Surg., 24 (5). S. 702 - 708. OXFORD: OXFORD UNIV PRESS. ISSN 1569-9285

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Abstract

OBJECTIVES: Previous research suggests that female gender is associated with increased mortality rates after surgery for Stanford A acute aortic dissection (AAD). However, women with AAD usually present with different clinical symptoms that may bias outcomes. Moreover, there is a lack of long-term results regarding overall mortality and freedom from major cerebrovascular events. We analysed the impact of gender on long-term outcomes after surgery for Stanford A AAD by comparing genders with similar risk profiles using propensity score matching. METHODS: A total of 240 patients operated for Stanford A AAD were included in this study. To control for selection bias and other con-founders, propensity score matching was applied to gender groups. RESULTS: After propensity score matching, the gender groups were well balanced in terms of risk profiles. There were no statistically significant differences regarding duration of cardiopulmonary bypass (P = 0.165) and duration of aortic cross-clamp time (P = 0.111). Female patients received less fresh frozen plasma (P = 0.021), had shorter stays in the intensive care unit (P = 0.031), lower incidence of temporary neurological dysfunction (P < 0.001) and lower incidence of dialysis (P = 0.008). There were no significant differences regarding intraoperative mortality (P = 1.000), 30-day mortality (P = 0.271), long-term overall cumulative survival (P = 0.954) and long-term freedom from cerebrovascular events (P = 0.235) with up to a 9-year follow-up. CONCLUSIONS: Considering patients with similar risk profiles, female gender per se is not associated with worse long-term survival and freedom from stroke after surgical aortic repair. Moreover, female patients might even benefit from a smoother early postoperative course and lower incidence of early postoperative complications.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sabashnikov, AntonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinen, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deppe, Antje ChristinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeriouh, MohamedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weymann, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Slottosch, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eghbalzadeh, KavehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popov, Aron-FrederikUNSPECIFIEDorcid.org/0000-0003-4226-3004UNSPECIFIED
Liakopoulos, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahmanian, Parwis B.UNSPECIFIEDorcid.org/0000-0002-3978-9251UNSPECIFIED
Madershahian, NavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kroener, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Choi, Yeong-HoonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuhn-Regnier, FerdinandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simon, Andre R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wahlers, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wippermann, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-233243
DOI: 10.1093/icvts/ivw426
Journal or Publication Title: Interact Cardiovasc. Thorac. Surg.
Volume: 24
Number: 5
Page Range: S. 702 - 708
Date: 2017
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1569-9285
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RISK-FACTORS; SURVIVALMultiple languages
Cardiac & Cardiovascular Systems; Respiratory System; SurgeryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23324

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