Universität zu Köln

Laufs, Ulrich, Filipiak, Krysztof J., Gouni-Berthold, Ioanna and Catapano, Alberico L. (2017). Practical aspects in the management of statin-associated muscle symptoms (SAMS). Atheroscler. Suppl., 26. S. 45 - 56. CLARE: ELSEVIER IRELAND LTD. ISSN 1878-5050

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Abstract

Background and aims: Statin-associated muscle symptoms (SAMS) frequently cause statin non-adherence, switching and discontinuation, contributing to adverse cardiovascular (CV) outcomes. Therefore, the management of SAMS is key in the effective treatment of patients with cardiovascular disease (CVD), through achievement of maximum-tolerated statin dosing and other practical aspects. The aim of this article is to provide practical, focused advice for healthcare professionals on the management of patients with SAMS. Methods: An expert working group combined current evidence, published guidelines and experiences surrounding a number of topics concerning SAMS to provide recommendations on how to best assess and manage this condition and reach the highest tolerated dose of statin for each individual patient. Results: The group collaborated to provide guidance on definitions in the SAMS field, psychological issues, re-challenging and switching treatments, as well as interpretation of current guidelines and optimal treatment of SAMS in different patient populations. An algorithm was developed to guide the management of patients with SAMS. In addition, the expert working group considered some of the more complex scenarios in a series of frequently asked questions and suggested answers. Conclusions: The expert working group gave recommendations for healthcare professionals on the management of SAMS but highlighted the importance of tailoring the treatment approach to each individual patient. Evidence supporting the role of nutraceuticals and complementary therapies, such as vitamin D, was lacking, however the majority of the group favoured combination therapy with ezetimibe and the addition of PCSK9 inhibitors in high-risk patients. (C) 2017 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Laufs, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Filipiak, Krysztof J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gouni-Berthold, Ioanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Catapano, Alberico L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-235843
DOI:	10.1016/S1567-5688(17)30024-7
Journal or Publication Title:	Atheroscler. Suppl.
Volume:	26
Page Range:	S. 45 - 56
Date:	2017
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1878-5050
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RED YEAST RICE; INTOLERANT PATIENTS; CREATINE-KINASE; DOUBLE-BLIND; THERAPY; DYSLIPIDEMIA; EZETIMIBE; MYOPATHY; HYPERCHOLESTEROLEMIA; SUPPLEMENTATION Multiple languages Peripheral Vascular Disease Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23584