Hombach, Andreas A. and Abken, Hinrich (2017). Shared target antigens on cancer cells and tissue stem cells: go or no-go for CAR T cells? Expert Rev. Clin. Immunol., 13 (2). S. 151 - 156. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1744-8409
Full text not available from this repository.Abstract
Introduction: Adoptive therapy with chimeric antigen receptor (CAR) T cells redirected towards CD19 produces remissions of B cell malignancies, however, it also eradicates healthy B cells sharing the target antigen. Such on-target off-tumor' toxicity raises serious safety concerns when the target antigen is also expressed by tissue stem cells, with the risk of lasting tissue destruction.Areas covered: We discuss CAR T cell targeting of activation antigens versus lineage associated antigens on the basis of recent experimental and animal data and the literature in the field.Expert commentary: Targeting an activation associated antigen which is transiently expressed by stem cells seems to be safe, like CAR T cells targeting CD30 spare CD30(+) hematopoietic stem and progenitor cells while eliminating CD30(+) lymphoma cells, whereas targeting lineage associated antigens which increase in expression during cell maturation, like folate receptor- and CD123, is of risk to destruct tissue stem cells.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-241407 | ||||||||||||
DOI: | 10.1080/1744666X.2016.1221763 | ||||||||||||
Journal or Publication Title: | Expert Rev. Clin. Immunol. | ||||||||||||
Volume: | 13 | ||||||||||||
Number: | 2 | ||||||||||||
Page Range: | S. 151 - 156 | ||||||||||||
Date: | 2017 | ||||||||||||
Publisher: | TAYLOR & FRANCIS LTD | ||||||||||||
Place of Publication: | ABINGDON | ||||||||||||
ISSN: | 1744-8409 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
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Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/24140 |
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