Universität zu Köln

Hombach, Andreas A. and Abken, Hinrich (2017). Shared target antigens on cancer cells and tissue stem cells: go or no-go for CAR T cells? Expert Rev. Clin. Immunol., 13 (2). S. 151 - 156. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1744-8409

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Abstract

Introduction: Adoptive therapy with chimeric antigen receptor (CAR) T cells redirected towards CD19 produces remissions of B cell malignancies, however, it also eradicates healthy B cells sharing the target antigen. Such on-target off-tumor' toxicity raises serious safety concerns when the target antigen is also expressed by tissue stem cells, with the risk of lasting tissue destruction.Areas covered: We discuss CAR T cell targeting of activation antigens versus lineage associated antigens on the basis of recent experimental and animal data and the literature in the field.Expert commentary: Targeting an activation associated antigen which is transiently expressed by stem cells seems to be safe, like CAR T cells targeting CD30 spare CD30(+) hematopoietic stem and progenitor cells while eliminating CD30(+) lymphoma cells, whereas targeting lineage associated antigens which increase in expression during cell maturation, like folate receptor- and CD123, is of risk to destruct tissue stem cells.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hombach, Andreas A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Abken, Hinrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-241407
DOI:	10.1080/1744666X.2016.1221763
Journal or Publication Title:	Expert Rev. Clin. Immunol.
Volume:	13
Number:	2
Page Range:	S. 151 - 156
Date:	2017
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1744-8409
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE MYELOID-LEUKEMIA; MAJOR HISTOCOMPATIBILITY COMPLEX; NEOPLASTIC LYMPHOID-TISSUE; CD30 EXPRESSION; ANTITUMOR-ACTIVITY; THERAPEUTIC INDEX; HODGKINS-DISEASE; RECEPTOR; LYMPHOCYTES; RECOGNITION Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24140