Gambichler, T., Wieland, U., Silling, S., Dreissigacker, M., Schaller, J., Schulze, H. -J., Oellig, F., Kreuter, A., Stuecker, M., Bechara, F. G., Stockfleth, E. and Becker, J. C. (2017). Left-sided laterality of Merkel cell carcinoma in a German population: more than just sun exposure. J. Cancer Res. Clin. Oncol., 143 (2). S. 347 - 351. NEW YORK: SPRINGER. ISSN 1432-1335

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Abstract

Lateral distribution of cancer has been observed previously. Most evident is this laterality in ultraviolet (UV)-induced skin cancer, based on an unequally distributed UV exposure. The aim of this study was to explore whether patients from Germany also show asymmetrical lateral distribution of Merkel cell carcinoma (MCC). In total, 115 patients with MCC were studied for laterality of the primary tumour. Correlation of clinical variables with lateral distribution of MCC was investigated as well. In 64/115 (55.7%) patients, primary tumours were present on the left side, in 37/115 (32.2%) on the right side, and in 14/115 (12.2%) in the midline (P < 0.0001). Excluding the latter localization occurrence of left-sided MCCs (64 of 101/63.4%) was significantly (P = 0.0072) more often observed (1.73-fold) when compared to right-sided tumours (37 of 101/36.6%). The excess of left-sided tumours was found on the head with a left-right ratio of 1.8, trunk of 8, arm of 1.2, and leg of 1.8. There was no significant association between laterality and gender, age, MCPyV status, and anatomic localization of primary tumours including the occurrence in sun-exposed sites. Occurrence of left-sided MCCs was significantly more often observed when compared to right-sided tumours. Laterality was not associated with tumour presentation at chronically ultraviolet-exposed sites. Hence, the reason for laterality in MCC remains obscure, but likely goes beyond UV exposure.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gambichler, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wieland, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silling, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dreissigacker, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaller, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulze, H. -J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oellig, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreuter, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stuecker, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bechara, F. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stockfleth, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, J. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-241425
DOI: 10.1007/s00432-016-2293-2
Journal or Publication Title: J. Cancer Res. Clin. Oncol.
Volume: 143
Number: 2
Page Range: S. 347 - 351
Date: 2017
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-1335
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LEFT-RIGHT ASYMMETRY; CUTANEOUS MELANOMA; UNITED-STATES; POLYOMAVIRUS; CANCER; SKIN; PATHWAYS; EXCESSMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24142

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