Universität zu Köln

Mombo, Illich Manfred, Lukashev, Alexander N., Bleicker, Tobias, Bruenink, Sebastian, Berthet, Nicolas, Maganga, Gael D., Durand, Patrick, Arnathau, Celine, Boundenga, Larson, Ngoubangoye, Barthelemy, Boue, Vanina, Liegeois, Florian, Ollomo, Benjamin, Prugnolle, Franck, Drexler, Jan Felix ORCID: 0000-0002-3509-0232, Drosten, Christian, Renaud, Francois, Rougeron, Virginie ORCID: 0000-0001-5873-5681 and Leroy, Eric (2017). African Non-Human Primates Host Diverse Enteroviruses. PLoS One, 12 (1). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Enteroviruses (EVs) belong to the family Picornaviridae and are responsible for mild to severe diseases in mammals including humans and non-human primates (NHP). Simian EVs were first discovered in the 1950s in the Old World Monkeys and recently in wild chimpanzee, gorilla and mandrill in Cameroon. In the present study, we screened by PCR EVs in 600 fecal samples of wild apes and monkeys that were collected at four sites in Gabon. A total of 32 samples were positive for EVs (25 from mandrills, 7 from chimpanzees, none from gorillas). The phylogenetic analysis of VP1 and VP2 genes showed that EVs identified in chimpanzees were members of two human EV species, EV-A and EV-B, and those identified in mandrills were members of the human species EV-B and the simian species EV-J. The identification of two novel enterovirus types, EV-B112 in a chimpanzee and EV-B113 in a mandrill, suggests these NHPs could be potential sources of new EV types. The identification of EV-B107 and EV90 that were previously found in humans indicates cross-species transfers. Also the identification of chimpanzee-derived EV110 in a mandrill demonstrated a wide host range of this EV. Further research of EVs in NHPs would help understanding emergence of new types or variants, and evaluating the real risk of cross-species transmission for humans as well for NHPs populations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mombo, Illich Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Lukashev, Alexander N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bleicker, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruenink, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Berthet, Nicolas UNSPECIFIED UNSPECIFIED UNSPECIFIED Maganga, Gael D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Durand, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Arnathau, Celine UNSPECIFIED UNSPECIFIED UNSPECIFIED Boundenga, Larson UNSPECIFIED UNSPECIFIED UNSPECIFIED Ngoubangoye, Barthelemy UNSPECIFIED UNSPECIFIED UNSPECIFIED Boue, Vanina UNSPECIFIED UNSPECIFIED UNSPECIFIED Liegeois, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ollomo, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Prugnolle, Franck UNSPECIFIED UNSPECIFIED UNSPECIFIED Drexler, Jan Felix UNSPECIFIED orcid.org/0000-0002-3509-0232 UNSPECIFIED Drosten, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Renaud, Francois UNSPECIFIED UNSPECIFIED UNSPECIFIED Rougeron, Virginie UNSPECIFIED orcid.org/0000-0001-5873-5681 UNSPECIFIED Leroy, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-242545
DOI:	10.1371/journal.pone.0169067
Journal or Publication Title:	PLoS One
Volume:	12
Number:	1
Date:	2017
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMPLETE GENOME SEQUENCES; MOLECULAR-IDENTIFICATION; PLASMODIUM-FALCIPARUM; MAXIMUM-LIKELIHOOD; VIRUS TYPE-1; EBOLA-VIRUS; EVOLUTION; RNA; RECOMBINATION; AMPLIFICATION Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24254