Dronse, Julian, Fliessbach, Klaus, Bischof, Gerard N., von Reutern, Boris, Faber, Jennifer, Hammes, Jochen, Kuhnert, Georg, Neumaier, Bernd ORCID: 0000-0001-5425-3116, Onur, Oezguer A., Kukolja, Juraj ORCID: 0000-0003-1569-3287, van Eimeren, Thilo ORCID: 0000-0002-6951-2325, Jessen, Frank, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Klockgether, Thomas and Drzezga, Alexander (2017). In vivo Patterns of Tau Pathology, Amyloid-beta Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease. J. Alzheimers Dis., 55 (2). S. 465 - 472. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

The clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition of amyloid-beta. We assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of Alzheimer's disease using novel multimodal PET imaging techniques. Tau pathology was primarily observed in brain regions related to clinical symptoms and overlapped with areas of hypometabolism. In contrast, amyloid-beta deposition was diffusely distributed over the entire cortex. Tau PET imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of Alzheimer's disease.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Dronse, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fliessbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bischof, Gerard N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Reutern, BorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faber, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hammes, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuhnert, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumaier, BerndUNSPECIFIEDorcid.org/0000-0001-5425-3116UNSPECIFIED
Onur, Oezguer A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kukolja, JurajUNSPECIFIEDorcid.org/0000-0003-1569-3287UNSPECIFIED
van Eimeren, ThiloUNSPECIFIEDorcid.org/0000-0002-6951-2325UNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Klockgether, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-243572
DOI: 10.3233/JAD-160316
Journal or Publication Title: J. Alzheimers Dis.
Volume: 55
Number: 2
Page Range: S. 465 - 472
Date: 2017
Publisher: IOS PRESS
Place of Publication: AMSTERDAM
ISSN: 1875-8908
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NEUROPATHOLOGICALLY DEFINED SUBTYPES; POSTERIOR CORTICAL ATROPHY; NEUROFIBRILLARY TANGLES; HYPOMETABOLISMMultiple languages
NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24357

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