Universität zu Köln

Weymann, Alexander, Sabashnikov, Anton, Ali-Hasan-Al-Saegh, Sadeq ORCID: 0000-0001-6312-1705, Popov, Aron-Frederik ORCID: 0000-0003-4226-3004, Mirhosseini, Seyed Jalil, Baker, William L. ORCID: 0000-0003-2172-0931, Lotfaliani, Mohammadreza, Liu, Tong, Dehghan, Hamidreza, Yavuz, Senol ORCID: 0000-0001-5246-0808, Barros de Oliveira Sa, Michel Pompeu, Jang, Jae-Sik, Zeriouh, Mohamed, Meng, Lei, D'Ascenzo, Fabrizio ORCID: 0000-0002-6646-9317, Deshmukh, Abhishek J., Biondi-Zoccai, Giuseppe ORCID: 0000-0001-6103-8510, Dohmen, Pascal M. and Calkins, Hugh (2017). Predictive Role of Coagulation, Fibrinolytic, and Endothelial Markers in Patients with Atrial Fibrillation, Stroke, and Thromboembolism: A Meta-Analysis, Meta-Regression, and Systematic Review. Med. Sci. Monit. Basic Res., 23. S. 97 - 141. MELVILLE: INT SCIENTIFIC INFORMATION, INC. ISSN 2325-4394

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Abstract

Background: The pathophysiological mechanism associated with the higher prothrombotic tendency in atrial fibrillation (AF) is complex and multifactorial. However, the role of prothrombotic markers in AF remains inconclusive. Material/Methods: We conducted a meta-analysis of observational studies evaluating the association of coagulation activation, fibrinolytic, and endothelial function with occurrence of AF and clinical adverse events. A comprehensive subgroup analysis and meta-regression was performed to explore potential sources of heterogeneity. Results: A literature search of major databases retrieved 1703 studies. After screening, a total of 71 studies were identified. Pooled analysis showed the association of coagulation markers (D-dimer (weighted mean difference (WMD)=197.67 and p<0.001), fibrinogen (WMD=0.43 and p<0.001), prothrombin fragment 1-2 (WMD=0.53 and p<0.001), antithrombin III (WMD=23.90 and p=0.004), thrombin-antithrombin (WMD=5.47 and p=0.004)); fibrinolytic markers (tissue-type plasminogen activator (t-PA) (WMD=2.13 and p<0.001), plasminogen activator inhibitor (WMD=11.44 and p<0.001), fibrinopeptide-A (WMD=4.13 and p=0.01)); and endothelial markers (von Willebrand factor (WMD=27.01 and p<0.001) and soluble thrombomodulin (WMD=3.92 and p<0.001)) with AF. Conclusions: The levels of coagulation, fibrinolytic, and endothelial markers have been reported to be significantly higher in AF patients than in SR patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weymann, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabashnikov, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Ali-Hasan-Al-Saegh, Sadeq UNSPECIFIED orcid.org/0000-0001-6312-1705 UNSPECIFIED Popov, Aron-Frederik UNSPECIFIED orcid.org/0000-0003-4226-3004 UNSPECIFIED Mirhosseini, Seyed Jalil UNSPECIFIED UNSPECIFIED UNSPECIFIED Baker, William L. UNSPECIFIED orcid.org/0000-0003-2172-0931 UNSPECIFIED Lotfaliani, Mohammadreza UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Tong UNSPECIFIED UNSPECIFIED UNSPECIFIED Dehghan, Hamidreza UNSPECIFIED UNSPECIFIED UNSPECIFIED Yavuz, Senol UNSPECIFIED orcid.org/0000-0001-5246-0808 UNSPECIFIED Barros de Oliveira Sa, Michel Pompeu UNSPECIFIED UNSPECIFIED UNSPECIFIED Jang, Jae-Sik UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeriouh, Mohamed UNSPECIFIED UNSPECIFIED UNSPECIFIED Meng, Lei UNSPECIFIED UNSPECIFIED UNSPECIFIED D'Ascenzo, Fabrizio UNSPECIFIED orcid.org/0000-0002-6646-9317 UNSPECIFIED Deshmukh, Abhishek J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Biondi-Zoccai, Giuseppe UNSPECIFIED orcid.org/0000-0001-6103-8510 UNSPECIFIED Dohmen, Pascal M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Calkins, Hugh UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243748
DOI:	10.12659/MSMBR.902558
Journal or Publication Title:	Med. Sci. Monit. Basic Res.
Volume:	23
Page Range:	S. 97 - 141
Date:	2017
Publisher:	INT SCIENTIFIC INFORMATION, INC
Place of Publication:	MELVILLE
ISSN:	2325-4394
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VON-WILLEBRAND-FACTOR; SPONTANEOUS ECHO CONTRAST; SOLUBLE P-SELECTIN; PLATELET ACTIVATION; PROTHROMBOTIC STATE; D-DIMER; HYPERCOAGULABLE STATE; MITRAL-STENOSIS; ISCHEMIC-STROKE; ELEVATED LEVELS Multiple languages Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24374