Universität zu Köln

Timmermann, Lars, Oehlwein, Christian, Ransmayr, Gerhard, Froehlich, Holger, Will, Edgar, Schroeder, Hanna, Lauterbach, Thomas, Bauer, Lars and Kassubek, Jan ORCID: 0000-0002-7106-9270 (2017). Patients' perception of Parkinson's disease-associated pain following initiation of rotigotine: a multicenter non-interventional study. Postgrad. Med., 129 (1). S. 46 - 55. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1941-9260

Full text not available from this repository.

Abstract

Objectives: To evaluate Parkinson's disease (PD)-associated pain as perceived by the patients (subjective characterization), and how this may change following initiation of rotigotine transdermal patch. Methods: SP1058 was a non-interventional study conducted in routine clinical practice in Germany and Austria in patients experiencing PD-associated pain (per the physician's assessment). Data were collected at baseline (ie, before rotigotine initiation) and at a routine visit after >= 25 days (-3 days allowed) of treatment on a maintenance dose of rotigotine (end of study [EoS]). Pain perception was assessed using the 12-item Pain Description List of the validated German Pain Questionnaire (each item ranked 0 = 'not true' to 3 = 'very true'). Primary effectiveness variable: change from baseline to EoS in the sum score of the 4 'affective dimension' items of the Pain Description List. Secondary effectiveness variables: change from baseline to EoS in Unified Parkinson's Disease Rating Scale (UPDRS) II, III, and II+III scores, and Parkinson's Disease Questionnaire (PDQ-8) total score (PD-related quality-of-life). Other variables included scores of the eight 'sensory dimension' items of the Pain Description List. Results: Of 93 enrolled patients (mean [SD] age: 71.1 [9.0] years; male: 48 [52%]), 77 (83%) completed the study, and 70 comprised the full analysis set. The mean (SD) change from baseline in the sum score of the four 'affective dimension' items was-1.3 (2.8) indicating a numerical improvement (baseline: 3.9 [3.4]). In the 'sensory dimension', pain was mostly perceived as 'pulling' at baseline (49/70 [70%]); ' largely true'/' very true'). Numerical improvements were observed in all UPDRS scores (mean [SD] change in UPDRS II+ III:-5.3 [10.5]; baseline: 36.0 [15.9]), and in PDQ-8 total score (-2.0 [4.8]; baseline: 10.7 [5.9]). Adverse drug reactions were consistent with dopaminergic stimulation and transdermal administration. Conclusion: The perception of the 'affective dimension' of PD-associated pain numerically improved in patients treated with rotigotine.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Oehlwein, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ransmayr, Gerhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Froehlich, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Will, Edgar UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeder, Hanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Lauterbach, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassubek, Jan UNSPECIFIED orcid.org/0000-0002-7106-9270 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243938
DOI:	10.1080/00325481.2017.1258953
Journal or Publication Title:	Postgrad. Med.
Volume:	129
Number:	1
Page Range:	S. 46 - 55
Date:	2017
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1941-9260
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSDERMAL ROTIGOTINE; CONTROLLED-TRIAL; DOUBLE-BLIND; THRESHOLD; LEVODOPA; PLACEBO; PROFILE; PATCH Multiple languages Medicine, General & Internal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24393