Universität zu Köln

Kumari, Snehlata and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2017). Epithelial Cell Death and Inflammation in Skin. In: Current Topics in Microbiology and Immunology, S. 77 - 94. BERLIN: SPRINGER-VERLAG BERLIN. ISBN 978-3-319-23913-2; 978-3-319-23912-5

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Abstract

The presence of dying cells in inflamed tissues has been recognized since many years, but until recently cell death was considered primarily a consequence of inflammation. Recent data in mouse models suggest that cell death could provide a potent trigger of inflammation. The identification of necroptosis as a new type of regulated necrotic cell death that is induced by death receptors, toll like receptors and type I interferon receptor indicated that necroptosis could contribute to the proinflammatory properties of these receptors. This is particularly relevant to the skin, a tissue that provides a life-sustaining structural and immunological barrier with the environment and is constantly exposed to mechanical, chemical, and microbial insults. Studies in mouse models showed that sensitization of keratinocytes to apoptosis or necroptosis triggered by TNF and other stimuli causes severe chronic inflammatory skin lesions. In addition, keratinocyte death is a prominent histopathological feature of many inflammatory skin diseases, suggesting that death of epithelial cells could contribute to the pathogenesis of skin inflammation. Here we review recent studies in genetic mouse models providing evidence that keratinocyte death is a potent trigger of skin inflammation and discuss their potential relevance for human inflammatory skin diseases.

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code Kumari, Snehlata UNSPECIFIED UNSPECIFIED UNSPECIFIED Pasparakis, Manolis UNSPECIFIED orcid.org/0000-0002-9870-0966 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-246471
DOI:	10.1007/82_2015_466
Title of Book:	Current Topics in Microbiology and Immunology
Series Name:	Curr.Top.Microbiol.Immunol.
Volume:	403
Page Range:	S. 77 - 94
Date:	2017
Publisher:	SPRINGER-VERLAG BERLIN
Place of Publication:	BERLIN
ISSN:	2196-9965
ISBN:	978-3-319-23913-2; 978-3-319-23912-5
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NF-KAPPA-B; MIXED LINEAGE KINASE; PROGRAMMED NECROSIS; DOMAIN-LIKE; EPIDERMAL-KERATINOCYTES; MOUSE MODEL; RIP3; APOPTOSIS; CASPASE-8; MICE Multiple languages Immunology; Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24647