Breyer, Johannes, Otto, Wolfgang, Wirtz, Ralph M., Wullich, Bernd, Keck, Bastian, Erben, Philipp ORCID: 0000-0002-8279-7636, Kriegmair, Maximilian C., Stoehr, Robert, Eckstein, Markus, Laible, Mark, Schlombs, Kornelia, Eidt, Sebastian, Denzinger, Stefan, Burger, Maximilian and Hartmann, Arndt (2017). ERBB2 Expression as Potential Risk-Stratification for Early Cystectomy in Patients with pT1 Bladder Cancer and Concomitant Carcinoma in situ. Urol.Int., 98 (3). S. 282 - 290. BASEL: KARGER. ISSN 1423-0399

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Abstract

Background/Aims/Objectives: It is difficult to identify patients with a non-muscle-invasive bladder cancer (NMIBC) at stage pT1 with concomitant carcinoma in situ (Cis) who will benefit from an early cystectomy. Methods: We retrospectively analyzed clinical data and formalin-fixed paraffin-embedded tissues of patients with NMIBC. Messenger ribonucleic acid (mRNA) expression of progesterone receptor (PGR), estrogen receptor (ESR1), ERBB2, and marker of proliferation Ki-67 (MKI67) was measured by single-step reverse transcription quantitative real-time polymerase chain reaction using RNA-specific TaqMan assays. Relative gene expression was determined by the normalization of 2 reference genes (CALM2, B2M) using the 40 Delta Delta CT method and relative gene expression was correlated to the histopathological stage and oncological outcome. Results: Of 302 patients with pT1 NMIBC in the initial transurethral resection of the bladder, 65 had a concomitant Cis. Elevated ERBB2 expression (> 40.1) significantly correlated with progress in patients with and without concomitant Cis (p = 0.020 and p = 0.049, respectively). For the subgroup of pT1 with concomitant Cis, elevated ERBB2 expression significantly discriminated between a high-risk group of 55% progression-free survival (PFS) and a low-risk group of 90% PFS after a 5-year follow-up (p = 0.020). Coxregression analysis revealed ERBB2 expression as the only independent prognostic factor for PFS (p = 0.0037). Conclusions: High mRNA expression of ERBB2 can identify patients with pT1 NMIBC with concomitant Cis, who have a high risk of progression and might benefit from an early cystectomy. (C) 2016 S. Karger AG, Basel

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Breyer, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Otto, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wirtz, Ralph M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wullich, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keck, BastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erben, PhilippUNSPECIFIEDorcid.org/0000-0002-8279-7636UNSPECIFIED
Kriegmair, Maximilian C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoehr, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eckstein, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laible, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlombs, KorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eidt, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Denzinger, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burger, MaximilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, ArndtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-246519
DOI: 10.1159/000453670
Journal or Publication Title: Urol.Int.
Volume: 98
Number: 3
Page Range: S. 282 - 290
Date: 2017
Publisher: KARGER
Place of Publication: BASEL
ISSN: 1423-0399
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BACILLUS-CALMETTE-GUERIN; UROTHELIAL CARCINOMA; PROGNOSTIC-FACTORS; KI67 EXPRESSION; GRADE; HER2; P53; PROGRESSION; SURVIVAL; SUBTYPESMultiple languages
Urology & NephrologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24651

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