Universität zu Köln

Herling, Marco, Rengstl, Benjamin, Scholtysik, Rene, Hartmann, Sylvia, Kueppers, Ralf, Hansmann, Martin-Leo, Diebner, Hans H. ORCID: 0000-0002-7138-6372, Roeder, Ingo, Abken, Hinrich, Newrzela, Sebastian and Kirberg, Joerg (2017). Concepts in mature T-cell lymphomas - highlights from an international joint symposium on T-cell immunology and oncology. Leuk. Lymphoma, 58 (4). S. 788 - 797. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1029-2403

Full text not available from this repository.

Abstract

Growing attention in mature T-cell lymphomas/leukemias (MTCL) is committed to more accurate and meaningful classifications, improved pathogenetic concepts and expanded therapeutic options. This requires considerations of the immunologic concepts of T-cell homeostasis and the specifics of T-cell receptor (TCR) affinities and signaling. Scientists from various disciplines established the CONTROL-T research unit and in an international conference on MTCL they brought together experts from T-cell immunity, oncology, immunotherapy and systems biology. We report here meeting highlights on the covered topics of diagnostic pitfalls, implications by the new WHO classification, insights from discovered genomic lesions as well as TCR-centric concepts of cellular dynamics in host defense, auto-immunity and tumorigenic clonal escape, including predictions to be derived from in vivo imaging and mathematical modeling. Presentations on novel treatment approaches were supplemented by strategies of optimizing T-cell immunotherapies. Work packages, that in joint efforts would advance the field of MTCL more efficiently, are identified.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herling, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Rengstl, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Scholtysik, Rene UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Sylvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Kueppers, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansmann, Martin-Leo UNSPECIFIED UNSPECIFIED UNSPECIFIED Diebner, Hans H. UNSPECIFIED orcid.org/0000-0002-7138-6372 UNSPECIFIED Roeder, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Abken, Hinrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Newrzela, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirberg, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-247388
DOI:	10.1080/10428194.2016.1222381
Journal or Publication Title:	Leuk. Lymphoma
Volume:	58
Number:	4
Page Range:	S. 788 - 797
Date:	2017
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1029-2403
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROLYMPHOCYTIC LEUKEMIA; HODGKIN-LYMPHOMA; STAT3 MUTATIONS; EXPRESSION; DIVERSITY; TRANSPLANTATION; CLASSIFICATION; LYMPHOCYTES; ONCOGENESIS; REPERTOIRE Multiple languages Oncology; Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24738