Universität zu Köln

Mena, Wilson, Diegeimann, Soeren, Wegener, Chrietian and Ewer, John ORCID: 0000-0002-6806-3628 (2016). Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on down stream neuromodulators. eLife, 5. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

Neuropeptides play a key role in the regulation of behaviors and physiological responses including alertness, social recognition, and hunger, yet, their mechanism of action is poorly understood. Here, we focus on the endocrine control ecdysis behavior, which is used by arthropods to shed their cuticle at the end of every molt. Ecdysis is triggered by ETH (Ecdysis triggering hormone), and we show that the response of peptidergic neurons that produce CCAP (crustacean cardioactive peptide), which are key targets of ETH and control the onset of ecdysis behavior, depends fundamentally on the actions of neuropeptides produced by other direct targets of ETH and released in a broad paracrine manner within the CNS; by autocrine influences from the CCAP neurons themselves; and by inhibitory actions mediated by GABA. Our findings provide insights into how this critical insect behavior is controlled and general principles for understanding how neuropeptides organize neuronal activity and behaviors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mena, Wilson UNSPECIFIED UNSPECIFIED UNSPECIFIED Diegeimann, Soeren UNSPECIFIED UNSPECIFIED UNSPECIFIED Wegener, Chrietian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ewer, John UNSPECIFIED orcid.org/0000-0002-6806-3628 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-252445
DOI:	10.7554/eLife.19686
Journal or Publication Title:	eLife
Volume:	5
Date:	2016
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ECDYSIS-TRIGGERING HORMONE; LOBSTER STOMATOGASTRIC GANGLION; ECLOSION HORMONE; CAENORHABDITIS-ELEGANS; CRUSTACEAN NEUROPIL; BEHAVIORAL SEQUENCE; NEURAL CIRCUITS; NERVOUS-SYSTEM; INSECT ECDYSIS; ADULT ECDYSIS Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25244