Universität zu Köln

Chaudhuri, K. Ray, Qamar, Mubasher A., Rajah, Thadshani, Loehrer, Philipp, Sauerbier, Anna, Odin, Per and Jenner, Peter (2016). Non-oral dopaminergic therapies for Parkinson's disease: current treatments and the future. npj Parkinsons Dis., 2. LONDON: NATURE PUBLISHING GROUP. ISSN 2373-8057

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Abstract

Dysfunction of the gastrointestinal tract has now been recognized to affect all stages of Parkinson's disease (PD). The consequences lead to problems with absorption of oral medication, erratic treatment response, as well as silent aspiration, which is one of the key risk factors in developing pneumonia. The issue is further complicated by other gut abnormalities, such as small intestinal bacterial overgrowth (SIBO) and an altered gut microbiota, which occur in PD with variable frequency. Clinically, these gastrointestinal abnormalities might be associated with symptoms such as nausea, early-morning off, and frequent motor and non-motor fluctuations. Therefore, non-oral therapies that avoid the gastrointestinal system seem a rational option to overcome the problems of oral therapies in PD. Hence, several non-oral strategies have now been actively investigated and developed. The transdermal rotigotine patch, infusion therapies with apomorphine, intrajejunal levodopa, and the apomorphine pen strategy are currently in clinical use with a few others in development. In this review, we discuss and summarize the most recent developments in this field with a focus on non-oral dopaminergic strategies (excluding surgical interventions such as deep brain stimulation) in development or to be licensed for management of PD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chaudhuri, K. Ray UNSPECIFIED UNSPECIFIED UNSPECIFIED Qamar, Mubasher A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rajah, Thadshani UNSPECIFIED UNSPECIFIED UNSPECIFIED Loehrer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Sauerbier, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Odin, Per UNSPECIFIED UNSPECIFIED UNSPECIFIED Jenner, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-253281
DOI:	10.1038/npjparkd.2016.23
Journal or Publication Title:	npj Parkinsons Dis.
Volume:	2
Date:	2016
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2373-8057
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARBIDOPA INTESTINAL GEL; GASTROINTESTINAL MOTILITY PROBLEMS; ROTIGOTINE TRANSDERMAL PATCH; DOUBLE-BLIND; NONMOTOR SYMPTOMS; SUBCUTANEOUS APOMORPHINE; INTRAJEJUNAL LEVODOPA; INJECTED APOMORPHINE; MOTOR FLUCTUATIONS; CONTROLLED-TRIAL Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25328