Allanore, Yannick, Komocsi, Andras, Vettori, Serena ORCID: 0000-0001-5617-9829, Hachulla, Eric, Hunzelmann, Nicolas, Distler, Jorg, Avouac, Jerome, Gobeaux, Camille, Launay, David ORCID: 0000-0003-1840-1817, Czirjak, Laszlo, Kahan, Andre and Meune, Christophe (2016). N-terminal pro-brain natriuretic peptide is a strong predictor of mortality in systemic sclerosis. Int. J. Cardiol., 223. S. 385 - 390. CLARE: ELSEVIER IRELAND LTD. ISSN 1874-1754
Full text not available from this repository.Abstract
Objectives: Cardiovascular involvement is a major contributor to mortality in systemic sclerosis (SSc). We examined whether N-terminal pro-brain natriuretic peptide (NT-proBNP) is a reliable predictor of mortality in SSc. Methods and results: This multicentre prospective cohort study included 523 patients presenting with SSc, whose mean age was 54 +/- 13 years, mean disease duration 8 +/- 9 years, and diffuse cutaneous form in 168. Plasma NT-proBNP was measured at baseline and the patients were followed yearly. Overall mortality was measured at 3 years. At baseline, cardiovascular involvement was present in 37 patients, including 17 with pulmonary artery hypertension (PAH) and 20 with a left ventricular ejection fraction (LVEF) <55%. At 3 years, 32 (7%) patients had died. The median [25th-75th percentile] NT-proBNP concentration was 203 ng/l [129-514] in patients who died within 3 years, versus 88 ng/l [47-167] in survivors (P < 0.001). NT-proBNP was an independent predictor of 3-years mortality in multivariate analysis (P = 0.046). The optimal cut-off derived from the ROC curve was 129 ng/l; sensitivity and specificity to predict 3 y mortality were 78.1 and 66.7%. Using the previously recommended 125-ng/l concentration as threshold value, NT-proBNP reliably and independently predicted 3 year mortality, with a sensitivity of 78.1 and a negative predictive value of 97.6%, respectively (P = 0.006). The consideration of SSc patients without PAH or LVEF < 55% at baseline yielded similar results. Conclusion: NT-proBNP appears as a reliable and independent predictor of mortality in patients with SSc. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-255668 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1016/j.ijcard.2016.08.246 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Int. J. Cardiol. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Volume: | 223 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Page Range: | S. 385 - 390 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Date: | 2016 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Publisher: | ELSEVIER IRELAND LTD | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Place of Publication: | CLARE | ||||||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 1874-1754 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/25566 |
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