Universität zu Köln

Schulz, Alexandra, Daali, Samira, Javed, Mehreen, Fuchs, Paul Christian, Brockmann, Michael, Igressa, Alhadi and Charalampaki, Patra (2016). Presurgical mapping of basal cell carcinoma or squamous cell carcinoma by confocal laser endomicroscopy compared to traditional micrographic surgery: a single-centre prospective feasibility study. Eur. J. Dermatol., 26 (6). S. 572 - 580. MONTROUGE: JOHN LIBBEY EUROTEXT LTD. ISSN 1952-4013

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Abstract

Background: At present, no ideal diagnostic tools exist in the market to excise cancer tissue with the required safety margins and to achieve optimal aesthetic results using tissue-conserving techniques. Objectives: In this prospective study, confocal laser endomicroscopy (CLE) and the traditional gold standard of magnifying glasses (MG) were compared regarding the boundaries of in vivo basal cell carcinoma and squamous cell carcinoma. Materials & methods: Tumour diameters defined by both methods were measured and compared with those determined by histopathological examination. Nineteen patients were included in the study. Results: The CLE technique was found to be superior to excisional margins based on MG only. Re-excision was required in 68% of the cases following excision based on MG evaluation, but only in 27% of the cases for whom excision margins were based on CLE. Conclusion: Our results are promising regarding the distinction between tumour and healthy surrounding tissue, and indicate that presurgical mapping of basal cell carcinoma and squamous cell carcinoma is possible. The tool itself should be developed further with special attention to early detection of skin cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schulz, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Daali, Samira UNSPECIFIED UNSPECIFIED UNSPECIFIED Javed, Mehreen UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Paul Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Brockmann, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Igressa, Alhadi UNSPECIFIED UNSPECIFIED UNSPECIFIED Charalampaki, Patra UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-256202
DOI:	10.1684/ejd.2016.2874
Journal or Publication Title:	Eur. J. Dermatol.
Volume:	26
Number:	6
Page Range:	S. 572 - 580
Date:	2016
Publisher:	JOHN LIBBEY EUROTEXT LTD
Place of Publication:	MONTROUGE
ISSN:	1952-4013
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONINVASIVE DIAGNOSIS; MICROSCOPY; SKIN; MELANOMA; SUBTYPE Multiple languages Dermatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25620