Universität zu Köln

Warncke, K., Konrad, K., Kohne, E., Hammer, E., Ohlenschlaeger, U., Herrlinger, S., Jaeger, A. and Holl, R. W. (2016). Diabetes in Patients with ss-thalassemia or other Hemoglobinopathies - Analysis from the DPV Database. Klinische Padiatr., 228 (6-7). S. 307 - 313. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3824

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Abstract

Background: Diabetes mellitus is a common endocrinopathy in patients with thalassemia major, but the occurrence of hemoglobinopathies is rare in Germany and Western Europe. The longitudinal German-Austrian DPV (Diabetes Patienten Verlaufsdokumentation) registry allows a comprehensive characterization of this group of patients. Patients/methods: Patients from the DPV-registry aged<30 years with thalassemia major or other hemoglobinopathies were compared to patients with type 1 diabetes (T1D) and type 2 diabetes (T2D) using the statistical software SAS 9.4. Results: 94 patients (0.13% of patients) with hemoglobinopathies are registered in DPV. 82.4% of 17 patients with thalassemia major, 100% of 12 patients with sickle cell disease (SCD) and >90% of 65 patients with other hemoglobinopathies receive insulin treatment. In the majority of patients with thalassemia major, hemosiderosis is documented. Patients with thalassemia major developed diabetes at a median age of 14.6 [IQR 8.4-18.0] years (9.0 years [5.3-12.5] in T1D; 18.7 years [14.2-25.6] in TD2; both p<0.01). They show high HbA1c/fructosamine levels and frequent hypoglycemia, reflecting poor metabolic control. Conclusion: Diabetes in thalassemia major is probably caused by hemosiderosis due to polytransfusion, while patients with SCD/thalassemia minor are most likely affected by T1D. The high rate of hypoglycemia in patients with ss-thalassemia major may be caused by liver fibrosis and a lack of hepatic glycogen stores.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Warncke, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Konrad, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohne, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hammer, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ohlenschlaeger, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrlinger, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaeger, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holl, R. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-256800
DOI:	10.1055/s-0042-111691
Journal or Publication Title:	Klinische Padiatr.
Volume:	228
Number:	6-7
Page Range:	S. 307 - 313
Date:	2016
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3824
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language METABOLIC-CONTROL; CHILDREN; GERMANY; MELLITUS; AUTOIMMUNITY; ADOLESCENTS; PREDICTION; ANEMIA Multiple languages Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25680