Universität zu Köln

Indrakova, Adela, Maslanova, Ivana ORCID: 0000-0002-2597-2848, Kovacova, Viera, Doskar, Jiri and Pantucek, Roman ORCID: 0000-0002-3950-675X (2016). The evolutionary pathway of the staphylococcal cassette chromosome element. Biologia, 71 (11). S. 1195 - 1204. BERLIN: WALTER DE GRUYTER GMBH. ISSN 1336-9563

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Abstract

The staphylococcal cassette chromosome (SCC) element can carry resistance genes to antibiotics, disinfectants, and heavy metals, contributing to the survival of strains in the environment and causing difficulties in the treatment of staphylococcal infections. Methicillin resistance in staphylococci, which is of particular clinical significance, is encoded by staphylococcal cassette chromosome mec (SCCmec). Despite the importance of the SCC element and description of multiple nucleotide sequences, the information about its origin and evolution is still scarce. Here, we present a phylogenetic analysis of SCC elements that is unique in the use of whole SCC sequences. A phylogenetic tree for a noteworthy number of 81 SCC elements based on global sequence alignment was constructed. The SCC clustering did not reflect the genetic relationships of bacteria containing the SCC elements, but was done according to type, determined by the combination of mec gene complex class and ccr gene complex type. The results emphasise the horizontal gene transfer as a means of spread of SCC elements in bacterial strains. Overall, this study contributes to the understanding of SCC emergence, evolution, and dissemination.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Indrakova, Adela UNSPECIFIED UNSPECIFIED UNSPECIFIED Maslanova, Ivana UNSPECIFIED orcid.org/0000-0002-2597-2848 UNSPECIFIED Kovacova, Viera UNSPECIFIED UNSPECIFIED UNSPECIFIED Doskar, Jiri UNSPECIFIED UNSPECIFIED UNSPECIFIED Pantucek, Roman UNSPECIFIED orcid.org/0000-0002-3950-675X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-257626
DOI:	10.1515/biolog-2016-0156
Journal or Publication Title:	Biologia
Volume:	71
Number:	11
Page Range:	S. 1195 - 1204
Date:	2016
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	1336-9563
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COAGULASE-NEGATIVE STAPHYLOCOCCI; METHICILLIN-RESISTANT; MEC SCCMEC; AUREUS ST398; MAXIMUM-LIKELIHOOD; GENOME SEQUENCE; GENE-SEQUENCES; FITNESS COST; COMMUNITY; CLONES Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25762