Universität zu Köln

Burnett, C. Joseph, Li, Chia, Webber, Emily ORCID: 0000-0003-2893-7164, Tsaousidou, Eva ORCID: 0000-0003-2751-1911, Xue, Stephen Y., Bruening, Jens C. and Krashes, Michael J. (2016). Hunger-Driven Motivational State Competition. Neuron, 92 (1). S. 187 - 202. CAMBRIDGE: CELL PRESS. ISSN 1097-4199

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Abstract

Behavioral choice is ubiquitous in the animal kingdom and is central to goal-oriented behavior. Hypothalamic Agouti-related peptide (AgRP) neurons are critical regulators of appetite. Hungry animals, bombarded by multiple sensory stimuli, are known to modify their behavior during times of caloric need, rapidly adapting to a consistently changing environment. Utilizing ARC AgRP neurons as an entry point, we analyzed the hierarchical position of hunger related to rival drive states. Employing a battery of behavioral assays, we found that hunger significantly increases its capacity to suppress competing motivational systems, such as thirst, anxiety-related behavior, innate fear, and social interactions, often only when food is accessible. Furthermore, real-time monitoring of ARC AgRP activity revealed time-locked responses to conspecific investigation in addition to food presentation, further establishing that, even at the level of ARC AgRP neurons, choices are remarkably flexible computations, integrating internal state, external factors, and anticipated yield.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Burnett, C. Joseph UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Chia UNSPECIFIED UNSPECIFIED UNSPECIFIED Webber, Emily UNSPECIFIED orcid.org/0000-0003-2893-7164 UNSPECIFIED Tsaousidou, Eva UNSPECIFIED orcid.org/0000-0003-2751-1911 UNSPECIFIED Xue, Stephen Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krashes, Michael J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-258569
DOI:	10.1016/j.neuron.2016.08.032
Journal or Publication Title:	Neuron
Volume:	92
Number:	1
Page Range:	S. 187 - 202
Date:	2016
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1097-4199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FEEDING-BEHAVIOR; NEURAL CIRCUITS; NEUROPEPTIDE-Y; CONSUMMATORY BEHAVIORS; LATERAL HYPOTHALAMUS; DOPAMINE NEURONS; MICE; NUCLEUS; AGRP; ACTIVATION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25856