Ghadri, Jelena R., Sarcon, Annahita, Diekmann, Johanna, Bataiosu, Dana Roxana, Cammann, Victoria L., Jurisic, Stjepan, Napp, Lars Christian, Jaguszewski, Milosz ORCID: 0000-0002-2555-593X, Scherff, Frank, Brugger, Peter, Jancke, Lutz, Seifert, Burkhardt, Bax, Jeroen J., Ruschitzka, Frank, Luscher, Thomas F., Templin, Christian, Schwyzer, Moritz, Franke, Jennifer, Katus, Hugo A., Burgdorf, Christof, Schunkert, Heribert, Thiele, Holger, Bauersachs, Johann, Tschoepe, Carsten, Rajan, Lawrence, Michels, Guido, Pfister, Roman, Ukena, Christian, Boehm, Michael, Erbel, Raimund, Cuneo, Alessandro, Kuck, Karl-Heinz, Jacobshagen, Claudius, Hasenfuss, Gerd, Karakas, Mahir, Koenig, Wolfgang, Rottbauer, Wolfgang, Said, Samir M., Braun-Dullaeus, Ruediger C., Cuculi, Florim, Banning, Adrian ORCID: 0000-0002-2842-7861, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K. E. Juhani, Fijalkowski, Marcin, Rynkiewicz, Andrzej ORCID: 0000-0002-5284-9511, Opolski, Grzegorz, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan ORCID: 0000-0002-9240-6731, Galiuto, Leonarda, Crea, Filippo, Dichtl, Wolfgang ORCID: 0000-0002-0421-2110, Franz, Wolfgang M., Empen, Klaus, Felix, Stephan B., Delmas, Clement ORCID: 0000-0001-9180-9128, Lairez, Olivier, Erne, Paul and Prasad, Abhiram (2016). Happy heart syndrome: role of positive emotional stress in takotsubo syndrome. Eur. Heart J., 37 (37). S. 2823 - 2830. OXFORD: OXFORD UNIV PRESS. ISSN 1522-9645

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Abstract

Aims Takotsubo syndrome (TTS) is typically provoked by negative stressors such as grief, anger, or fear leading to the popular term broken heart syndrome. However, the role of positive emotions triggering TTS remains unclear. The aim of the present study was to analyse the prevalence and characteristics of patients with TTS following pleasant events, which are distinct from the stressful or undesirable episodes commonly triggering TTS. Methods and results Takotsubo syndrome patients with preceding pleasant events were compared to those with negative emotional triggers from the International Takotsubo Registry. Of 1750 TTS patients, we identified a total of 485 with a definite emotional trigger. Of these, 4.1% (n = 20) presented with pleasant preceding events and 95.9% (n = 465) with unequivocal negative emotional events associated with TTS. Interestingly, clinical presentation of patients with happy heart syndrome was similar to those with the broken heart syndrome including symptoms such as chest pain [89.5% (17/19) vs. 90.2% (412/457), P = 1.0]. Similarly, electrocardiographic parameters, laboratory findings, and 1-year outcome did not differ. However, in a post hoc analysis, a disproportionate higher prevalence of midventricular involvement was noted in happy hearts compared with broken hearts (35.0 vs. 16.3%, P = 0.030). Conclusion Our data illustrate that TTS can be triggered by not only negative but also positive life events. While patient characteristics were similar between groups, the midventricular TTS type was more prevalent among the happy hearts than among the broken hearts. Presumably, despite their distinct nature, happy and sad life events may share similar final common emotional pathways, which can ultimately trigger TTS.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ghadri, Jelena R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarcon, AnnahitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diekmann, JohannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bataiosu, Dana RoxanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cammann, Victoria L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jurisic, StjepanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Napp, Lars ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaguszewski, MiloszUNSPECIFIEDorcid.org/0000-0002-2555-593XUNSPECIFIED
Scherff, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brugger, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jancke, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seifert, BurkhardtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bax, Jeroen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruschitzka, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luscher, Thomas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Templin, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwyzer, MoritzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katus, Hugo A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burgdorf, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schunkert, HeribertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiele, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauersachs, JohannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tschoepe, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rajan, LawrenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michels, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, RomanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ukena, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boehm, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erbel, RaimundUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuneo, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuck, Karl-HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobshagen, ClaudiusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasenfuss, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karakas, MahirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rottbauer, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Said, Samir M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun-Dullaeus, Ruediger C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuculi, FlorimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Banning, AdrianUNSPECIFIEDorcid.org/0000-0002-2842-7861UNSPECIFIED
Fischer, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasankari, TuijaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Airaksinen, K. E. JuhaniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fijalkowski, MarcinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rynkiewicz, AndrzejUNSPECIFIEDorcid.org/0000-0002-5284-9511UNSPECIFIED
Opolski, GrzegorzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dworakowski, RafalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacCarthy, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osswald, StefanUNSPECIFIEDorcid.org/0000-0002-9240-6731UNSPECIFIED
Galiuto, LeonardaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crea, FilippoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dichtl, WolfgangUNSPECIFIEDorcid.org/0000-0002-0421-2110UNSPECIFIED
Franz, Wolfgang M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Empen, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Felix, Stephan B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delmas, ClementUNSPECIFIEDorcid.org/0000-0001-9180-9128UNSPECIFIED
Lairez, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erne, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prasad, AbhiramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-261461
DOI: 10.1093/eurheartj/ehv757
Journal or Publication Title: Eur. Heart J.
Volume: 37
Number: 37
Page Range: S. 2823 - 2830
Date: 2016
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1522-9645
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TAKO-TSUBO; CARDIOMYOPATHY; FEATURES; AMYGDALA; SUDDEN; POWER; TIMEMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/26146

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