McAvoy, Kathleen M., Scobie, Kimberly N., Berger, Stefan, Russo, Craig, Guo, Nannan, Decharatanachart, Pakanat, Vega-Ramirez, Hugo, Miake-Lye, Sam, Whalen, Michael, Nelson, Mark, Bergami, Matteo ORCID: 0000-0001-5525-5025, Bartsch, Dusan, Hen, Rene, Berninger, Benedikt ORCID: 0000-0003-2652-2782 and Sahay, Amar (2016). Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits. Neuron, 91 (6). S. 1356 - 1374. CAMBRIDGE: CELL PRESS. ISSN 1097-4199

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Abstract

The neural circuit mechanisms underlying the integration and functions of adult-born dentate granule cell (DGCs) are poorly understood. Adult-born DGCs are thought to compete with mature DGCs for inputs to integrate. Transient genetic overexpression of a negative regulator of dendritic spines, Kruppel-like factor 9 (Klf9), in mature DGCs enhanced integration of adult-born DGCs and increased NSC activation. Reversal of Klf9 overexpression in mature DGCs restored spines and activity and reset neuronal competition dynamics and NSC activation, leaving the DG modified by a functionally integrated, expanded cohort of age-matched adult-born DGCs. Spine elimination by inducible deletion of Rac1 in mature DGCs increased survival of adult-born DGCs without affecting proliferation or DGC activity. Enhanced integration of adult-born DGCs transiently reorganized adult-born DGC local afferent connectivity and promoted global remapping in the DG. Rejuvenation of the DG by enhancing integration of adult-born DGCs in adulthood, middle age, and aging enhanced memory precision.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
McAvoy, Kathleen M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scobie, Kimberly N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berger, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Russo, CraigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guo, NannanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Decharatanachart, PakanatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vega-Ramirez, HugoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miake-Lye, SamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Whalen, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nelson, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergami, MatteoUNSPECIFIEDorcid.org/0000-0001-5525-5025UNSPECIFIED
Bartsch, DusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hen, ReneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berninger, BenediktUNSPECIFIEDorcid.org/0000-0003-2652-2782UNSPECIFIED
Sahay, AmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-262149
DOI: 10.1016/j.neuron.2016.08.009
Journal or Publication Title: Neuron
Volume: 91
Number: 6
Page Range: S. 1356 - 1374
Date: 2016
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1097-4199
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ADULT HIPPOCAMPAL NEUROGENESIS; ENHANCED SYNAPTIC PLASTICITY; PATTERN SEPARATION; GRANULE CELLS; CRITICAL PERIOD; OLFACTORY-BULB; BORN; MICE; AGE; REVEALSMultiple languages
NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/26214

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