Universität zu Köln

Andrade, Pablo ORCID: 0000-0002-2596-7301 and Visser-Vandewalle, Veerle (2016). DBS in Tourette syndrome: where are we standing now? J. Neural Transm., 123 (7). S. 791 - 797. WIEN: SPRINGER WIEN. ISSN 1435-1463

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Abstract

Deep brain stimulation (DBS) has emerged as an established effective and safe treatment option for a small subset of patients with severe Tourette syndrome (TS) refractory to psychological and pharmacological treatments. Several targets have been implicated in the study of the effects of DBS on TS symptomatology. The targets applied for DBS in TS include the thalamus, the globus pallidus internus, the internal capsule/nucleus accumbens, the globus pallidus externus and the subthalamic nucleus. In the majority of studies there has been a significant clinical benefit on tics. Nevertheless, the best target has not been defined yet. Up until now, only five double blind randomized controlled trials have been carried out worldwide for a total of 32 patients. Thus, the new recommendations for DBS in TS emphasize the importance of standardized recordings of all pre-, intra-, and postoperative data to optimize the registration of patients so that results can be compared. Recent reports have shown that standard continuous DBS for TS patients may not be the most optimal paradigms to pursue. Adaptive stimulation and the use of human-computer interfaces might in the future optimize the results of DBS in TS because of the paroxysmal nature of the disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Andrade, Pablo UNSPECIFIED orcid.org/0000-0002-2596-7301 UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-270955
DOI:	10.1007/s00702-016-1569-7
Journal or Publication Title:	J. Neural Transm.
Volume:	123
Number:	7
Page Range:	S. 791 - 797
Date:	2016
Publisher:	SPRINGER WIEN
Place of Publication:	WIEN
ISSN:	1435-1463
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; THALAMIC-STIMULATION; DOUBLE-BLIND; TRIAL; TICS; COMPLEXITIES; SURGERY; PATIENT Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27095