Merz, Maximilian, Jansen, Lina ORCID: 0000-0001-8004-4940, Castro, Felipe A., Hillengass, Jens, Salwender, Hans ORCID: 0000-0001-7803-0814, Weisel, Katja, Scheid, Christof, Luttmann, Sabine, Emrich, Katharina, Holleczek, Bernd, Katalinic, Alexander ORCID: 0000-0003-0490-1554, Nennecke, Alice, Straka, Christian, Langer, Christian, Engelhardt, Monika, Einsele, Hermann, Kroeger, Nicolaus, Beelen, Dietrich, Dreger, Peter, Brenner, Hermann ORCID: 0000-0002-6129-1572 and Goldschmidt, Hartmut (2016). Survival of elderly patients with multiple myeloma-Effect of upfront autologous stem cell transplantation. Eur. J. Cancer, 62. S. 1 - 9. OXFORD: ELSEVIER SCI LTD. ISSN 1879-0852

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Abstract

Background: The aim of this study was to determine the value of upfront autologous transplantation (ASCT) in elderly patients (60-79 years) with myeloma. Methods: We analysed relative survival (RS) of patients diagnosed in 1998-2011 and treated with ASCT within 12 months after diagnosis in Germany (n = 3591; German Registry of Stem Cell Transplantation) and compare RS with survival of myeloma patients diagnosed in the same years in Germany (n = 13,903; population-based German Cancer Registries). Results: Utilisation of ASCT has increased rapidly between 2000-2002 and 2009-2011 (60-64years: 7.0-43.0%; 65-69 years: 6.6-23.7%; 70-79 years: 0.4-4.0%). Comparison of 5-year RS of patients from the general German myeloma population who have survived the first year after diagnosis with 5-year RS of patients treated with ASCT revealed higher survival for transplanted patients among all age groups (60-64: 59.2% versus 66.1%; 65-69: 57.4% versus 61.7%; 70-79: 51.0% versus 56.6%). RS increased strongly between 2003-2005 and 2009 -2011 for the general German myeloma population (+8.5%) and for patients treated with ASCT (+11.8%). Differences in RS between these groups increased over time from +1.9% higher age-standardised survival in transplanted patients in 2003-2005 to 5.2% higher survival in 2009-2011. Conclusion: We conclude that upfront ASCT might be a major contributor to improved survival for elderly myeloma patients in Germany. (C) 2016 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Merz, MaximilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jansen, LinaUNSPECIFIEDorcid.org/0000-0001-8004-4940UNSPECIFIED
Castro, Felipe A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hillengass, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salwender, HansUNSPECIFIEDorcid.org/0000-0001-7803-0814UNSPECIFIED
Weisel, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheid, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luttmann, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emrich, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holleczek, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katalinic, AlexanderUNSPECIFIEDorcid.org/0000-0003-0490-1554UNSPECIFIED
Nennecke, AliceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Straka, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langer, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engelhardt, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Einsele, HermannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kroeger, NicolausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beelen, DietrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dreger, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brenner, HermannUNSPECIFIEDorcid.org/0000-0002-6129-1572UNSPECIFIED
Goldschmidt, HartmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-271796
DOI: 10.1016/j.ejca.2016.04.004
Journal or Publication Title: Eur. J. Cancer
Volume: 62
Page Range: S. 1 - 9
Date: 2016
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1879-0852
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LONG-TERM SURVIVAL; UP-TO-DATE; CANCER SURVIVAL; PERIOD ANALYSIS; IMPROVEMENT; MELPHALAN; THERAPYMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27179

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