Witkowski, Peter T. ORCID: 0000-0002-6167-8945, Drexler, Jan F., Kallies, Rene ORCID: 0000-0002-9195-0276, Lickova, Martina ORCID: 0000-0001-5357-6618, Bokorova, Silvia, Mananga, Gael D., Szemes, Tomas ORCID: 0000-0002-0900-2534, Leroy, Eric M., Krueger, Detlev H., Drosten, Christian and Klempa, Boris ORCID: 0000-0002-6931-1224 (2016). Phylogenetic analysis of a newfound bat-borne hantavirus supports a laurasiatherian host association for ancestral mammalian hantaviruses. Infect. Genet. Evol., 41. S. 113 - 120. AMSTERDAM: ELSEVIER. ISSN 1567-7257

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Abstract

Until recently, hantaviruses (family Bunyaviridae) were believed to originate from rodent reservoirs. However, genetically distinct hantaviruses were lately found in shrews and moles, as well as in bats from Africa and Asia. Bats (order Chiroptera) are considered important reservoir hosts for emerging human pathogens. Here, we report on the identification of a novel hantavirus, provisionally named Makokou virus (MAKV), in Noack's Roundleaf Bat (Hipposideros ruber) in Gabon, Central Africa. Phylogenetic analysis of the genomic L-segment showed that MAKV was the most closely related to other bat-borne hantaviruses and shared a most recent common ancestor with the Asian hantaviruses Xuan Son and Laibin. Breakdown of the virus load in a bat animal showed that MAKV resembles rodent-borne hantaviruses in its organ distribution in that it predominantly occurred in the spleen and kidney; this provides a first insight into the infection pattern of bat-borne hantaviruses. Ancestral state reconstruction based on a tree of L gene sequences of all relevant hantavirus lineages was combined with phylogenetic fossil host hypothesis testing, leading to a statistically significant rejection of the mammalian superorder Euarchontoglires (including rodents) but not the superorder Laurasiatheria (including shrews, moles, and bats) as potential hosts of ancestral hantaviruses at most basal tree nodes. Our data supports the emerging concept of bats as previously overlooked hantavirus reservoir hosts. (C) 2016 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Witkowski, Peter T.UNSPECIFIEDorcid.org/0000-0002-6167-8945UNSPECIFIED
Drexler, Jan F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kallies, ReneUNSPECIFIEDorcid.org/0000-0002-9195-0276UNSPECIFIED
Lickova, MartinaUNSPECIFIEDorcid.org/0000-0001-5357-6618UNSPECIFIED
Bokorova, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mananga, Gael D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szemes, TomasUNSPECIFIEDorcid.org/0000-0002-0900-2534UNSPECIFIED
Leroy, Eric M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krueger, Detlev H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drosten, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klempa, BorisUNSPECIFIEDorcid.org/0000-0002-6931-1224UNSPECIFIED
URN: urn:nbn:de:hbz:38-271842
DOI: 10.1016/j.meegid.2016.03.036
Journal or Publication Title: Infect. Genet. Evol.
Volume: 41
Page Range: S. 113 - 120
Date: 2016
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1567-7257
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
VIRUS; EVOLUTIONARY; MOUSE; SHREWMultiple languages
Infectious DiseasesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27184

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