Universität zu Köln

Bosche, Bert, Molcanyi, Marek, Noll, Thomas, Rej, Soham, Zatschler, Birgit, Doeppner, Thorsten R., Hescheler, Juergen, Mueller, Daniel J., Macdonald, R. Loch and Haertel, Frauke V. (2016). A differential impact of lithium on endothelium-dependent but not on endothelium-independent vessel relaxation. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 67. S. 98 - 107. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1878-4216

Full text not available from this repository.

Abstract

Lithium is drug for bipolar disorders with a narrow therapeutic window. Lithium was recently reported to prevent stroke and protect vascular endothelium but tends to accumulate particularly in the brain and kidney. Here, adverse effects are common; however mechanisms are still vaguely understood. If lithium could also negatively influence the endothelium is unclear. Wehypothesize that at higher lithium levels, the effects on endothelium reverses - that lithium also impairs endothelial-dependent relaxation of blood vessels. Vessel grafts from de-nerved murine aortas and porcine middle cerebral arteries were preconditioned using media supplemented with lithium chloride or acetate (0.4-100 mmol/L). Native or following phenylephrine-induced vasoconstriction, the relaxation capacity of preconditioned vessels was assessed by isometric myography, using acetylcholine to test the endothelium-dependent or sodium nitroprusside to test the endothelium-independent vasorelaxation, respectively. At the 0.4 mmol/L lithium concentration, acetylcholine-induced endothelium-dependent vessel relaxation was slightly increased, however, diminished in a concentration-dependent manner in vessel grafts preconditioned with lithium at higher therapeutic and supratherapeutic concentrations (0.8-100 mmol/L). In contrast, endothelium-independent vasorelaxation remained unaltered in preconditioned vessel grafts at any lithium concentration tested. Lithium elicits opposing effects on endothelial functions representing a differential impact on the endothelium within the narrow therapeutic window. Lithium accumulation or overdose reduces endothelium-dependent but not endothelium-independent vasorelaxation. The differentially modified endothelium-dependent vascular response represents an additional mechanism contributing to therapeutic or adverse effects of lithium. (C) 2016 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bosche, Bert UNSPECIFIED UNSPECIFIED UNSPECIFIED Molcanyi, Marek UNSPECIFIED UNSPECIFIED UNSPECIFIED Noll, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Rej, Soham UNSPECIFIED UNSPECIFIED UNSPECIFIED Zatschler, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Doeppner, Thorsten R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hescheler, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Daniel J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Macdonald, R. Loch UNSPECIFIED UNSPECIFIED UNSPECIFIED Haertel, Frauke V. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-272519
DOI:	10.1016/j.pnpbp.2016.02.004
Journal or Publication Title:	Prog. Neuro-Psychopharmacol. Biol. Psychiatry
Volume:	67
Page Range:	S. 98 - 107
Date:	2016
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1878-4216
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC KIDNEY-DISEASE; BIPOLAR DISORDER; INOSITOL TRISPHOSPHATE; DIABETES-MELLITUS; MOOD DISORDERS; NITRIC-OXIDE; CALCIUM; SYNTHASE; RISK; INTERVENTION Multiple languages Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27251