Universität zu Köln

Falgenhauer, Linda ORCID: 0000-0003-4706-8507, Imirzalioglu, Can, Ghosh, Hiren, Gwozdzinski, Konrad, Schmiedel, Judith, Gentil, Katrin, Bauerfeind, Rolf, Kaempfer, Peter, Seifert, Harald, Michael, Geovana Brenner, Schwarz, Stefan, Pfeifer, Yvonne, Werner, Guido, Pietsch, Michael ORCID: 0000-0003-4807-3244, Roesler, Uwe, Guerra, Beatriz, Fischer, Jennie, Sharp, Hannah, Kaesbohrer, Annemarie, Goesmann, Alexander ORCID: 0000-0002-7086-2568, Hille, Katja ORCID: 0000-0001-9483-1435, Kreienbrock, Lothar and Chakraborty, Trinad (2016). Circulation of clonal populations of fluoroquinolone-resistant CTX-M-15-producing Escherichia coli ST410 in humans and animals in Germany. Int. J. Antimicrob. Agents, 47 (6). S. 457 - 466. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-7913

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Abstract

Multidrug-resistant Escherichia coli encoding CTX-M-type extended-spectrum beta-lactamases (ESBLs) are isolated in increasing numbers from humans, companion animals and livestock, raising concern regarding the exchange and spread of isolates in these populations. In this study, whole-genome sequencing of CTX-M-15-producing E. coli isolates recently sampled from humans, companion animals, livestock and farm environments was performed. In total, 26 different sequence types (STs) were detected, of which ST410 was the most frequent and was the only ST present in all populations studied. Five clades (designated A-E) were detected within the ST410 isolates. In particular, isolates of clade B were present in all four populations and had core genomes that differed by less than 70 single nucleotide polymorphisms (SNPs). Isolates of clades B and C were also clonally marked, exhibiting identical chromosomal insertions of bla(CTX-M-15) at distinct loci. These data provide strong evidence for the clonal dissemination of specific clades of CTX-M-15-producing E. coli ST410 in human and animal populations. (C) 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Falgenhauer, Linda UNSPECIFIED orcid.org/0000-0003-4706-8507 UNSPECIFIED Imirzalioglu, Can UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghosh, Hiren UNSPECIFIED UNSPECIFIED UNSPECIFIED Gwozdzinski, Konrad UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmiedel, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Gentil, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauerfeind, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaempfer, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Seifert, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Michael, Geovana Brenner UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarz, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeifer, Yvonne UNSPECIFIED UNSPECIFIED UNSPECIFIED Werner, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Pietsch, Michael UNSPECIFIED orcid.org/0000-0003-4807-3244 UNSPECIFIED Roesler, Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Guerra, Beatriz UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Jennie UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharp, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaesbohrer, Annemarie UNSPECIFIED UNSPECIFIED UNSPECIFIED Goesmann, Alexander UNSPECIFIED orcid.org/0000-0002-7086-2568 UNSPECIFIED Hille, Katja UNSPECIFIED orcid.org/0000-0001-9483-1435 UNSPECIFIED Kreienbrock, Lothar UNSPECIFIED UNSPECIFIED UNSPECIFIED Chakraborty, Trinad UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-273847
DOI:	10.1016/j.ijantimicag.2016.03.019
Journal or Publication Title:	Int. J. Antimicrob. Agents
Volume:	47
Number:	6
Page Range:	S. 457 - 466
Date:	2016
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1872-7913
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LACTAMASE-PRODUCING ENTEROBACTERIACEAE; BETA-LACTAMASE; SEARCH TOOL; ALIGNMENT; SEQUENCE; COLONIZATION; SURVEILLANCE; NETHERLANDS; GENES Multiple languages Infectious Diseases; Microbiology; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27384